Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1441746..1442254 Replicon chromosome
Accession NZ_CP079921
Organism Actinobacillus pleuropneumoniae strain P1875

Toxin (Protein)


Gene name relE Uniprot ID B0BQK9
Locus tag KZH40_RS06530 Protein ID WP_005605064.1
Coordinates 1441994..1442254 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0BQK8
Locus tag KZH40_RS06525 Protein ID WP_005598318.1
Coordinates 1441746..1441997 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH40_RS06485 (KZH40_06540) 1437285..1437833 - 549 WP_005601803.1 type IV pilus biogenesis/stability protein PilW -
KZH40_RS06490 (KZH40_06545) 1437887..1439068 - 1182 WP_005601805.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
KZH40_RS06515 (KZH40_06570) 1439969..1441408 + 1440 WP_005601815.1 glutamate--tRNA ligase -
KZH40_RS06525 (KZH40_06580) 1441746..1441997 + 252 WP_005598318.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KZH40_RS06530 (KZH40_06585) 1441994..1442254 + 261 WP_005605064.1 Txe/YoeB family addiction module toxin Toxin
KZH40_RS06535 (KZH40_06590) 1442413..1442580 - 168 WP_005598320.1 Trm112 family protein -
KZH40_RS06540 (KZH40_06595) 1442582..1443562 - 981 WP_005601819.1 tetraacyldisaccharide 4'-kinase -
KZH40_RS06545 (KZH40_06600) 1443656..1444915 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
KZH40_RS06550 (KZH40_06605) 1444915..1445505 - 591 WP_005601821.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
KZH40_RS06555 (KZH40_06610) 1445629..1446021 + 393 WP_005618838.1 SufE family protein -
KZH40_RS06570 (KZH40_06625) 1446380..1447153 - 774 WP_005618837.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.99 Da        Isoelectric Point: 8.0109

>T210360 WP_005605064.1 NZ_CP079921:1441994-1442254 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

>T210360 NZ_CP104503:c3972926-3972774 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9362.66 Da        Isoelectric Point: 4.5659

>AT210360 WP_005598318.1 NZ_CP079921:1441746-1441997 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Download         Length: 252 bp

>AT210360 NZ_CP104503:3972975-3973032 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BQK9

Antitoxin

Source ID Structure
AlphaFold DB B0BQK8

References