Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 4707151..4707772 | Replicon | chromosome |
| Accession | NZ_CP079903 | ||
| Organism | Pseudomonas juntendi strain K37-3 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A2G8MXB6 |
| Locus tag | KZA81_RS21955 | Protein ID | WP_016715573.1 |
| Coordinates | 4707151..4707333 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | KZA81_RS21960 | Protein ID | WP_115293990.1 |
| Coordinates | 4707371..4707772 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZA81_RS21915 (KZA81_21780) | 4702763..4704448 | - | 1686 | WP_029885580.1 | terminase large subunit | - |
| KZA81_RS21920 (KZA81_21785) | 4704448..4704993 | - | 546 | WP_029885579.1 | terminase | - |
| KZA81_RS21925 (KZA81_21790) | 4705148..4705483 | - | 336 | WP_260777194.1 | HNH endonuclease signature motif containing protein | - |
| KZA81_RS21930 (KZA81_21795) | 4705483..4705641 | - | 159 | WP_260777195.1 | hypothetical protein | - |
| KZA81_RS21935 (KZA81_21800) | 4705653..4705883 | - | 231 | WP_260777196.1 | hypothetical protein | - |
| KZA81_RS21940 (KZA81_21805) | 4705899..4706129 | - | 231 | WP_260777197.1 | hypothetical protein | - |
| KZA81_RS21945 (KZA81_21810) | 4706177..4706494 | - | 318 | WP_260777198.1 | hypothetical protein | - |
| KZA81_RS21950 (KZA81_21815) | 4706494..4706865 | - | 372 | WP_260777199.1 | DUF3450 domain-containing protein | - |
| KZA81_RS21955 (KZA81_21820) | 4707151..4707333 | + | 183 | WP_016715573.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KZA81_RS21960 (KZA81_21825) | 4707371..4707772 | + | 402 | WP_115293990.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KZA81_RS21965 (KZA81_21830) | 4707879..4708268 | - | 390 | WP_260777202.1 | antiterminator Q family protein | - |
| KZA81_RS21970 (KZA81_21835) | 4708265..4708552 | - | 288 | WP_260777204.1 | hypothetical protein | - |
| KZA81_RS21975 (KZA81_21840) | 4708545..4709879 | - | 1335 | WP_260777206.1 | site-specific integrase | - |
| KZA81_RS21980 (KZA81_21845) | 4709866..4711257 | - | 1392 | WP_260777207.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| KZA81_RS21985 (KZA81_21850) | 4711254..4712054 | - | 801 | WP_260777211.1 | ATP-binding protein | - |
| KZA81_RS21990 (KZA81_21855) | 4712035..4712706 | - | 672 | WP_260777212.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 4668729..4710429 | 41700 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6696.86 Da Isoelectric Point: 11.2336
>T210359 WP_016715573.1 NZ_CP079903:4707151-4707333 [Pseudomonas juntendi]
VQSRQLIKELEAAGWVLKRVTGSHHIFKHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK
VQSRQLIKELEAAGWVLKRVTGSHHIFKHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK
Download Length: 183 bp
>T210359 NZ_CP104503:3860708-3860995 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14526.37 Da Isoelectric Point: 4.1955
>AT210359 WP_115293990.1 NZ_CP079903:4707371-4707772 [Pseudomonas juntendi]
MQYPICIEWGDENTATGIQIPDIPGAVTAGDTFEEAYSAAVEVAHIMLEEIASNGQAIPMPTSAAAHRDNPDFADMGWGM
LEIDITPYLGKTEKVNVTLPGFVIQQIDRYVRDHNVKSRSSFLADAAMEKLGR
MQYPICIEWGDENTATGIQIPDIPGAVTAGDTFEEAYSAAVEVAHIMLEEIASNGQAIPMPTSAAAHRDNPDFADMGWGM
LEIDITPYLGKTEKVNVTLPGFVIQQIDRYVRDHNVKSRSSFLADAAMEKLGR
Download Length: 402 bp
>AT210359 NZ_CP104503:3860982-3861284 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|