Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3388463..3389084 | Replicon | chromosome |
| Accession | NZ_CP079903 | ||
| Organism | Pseudomonas juntendi strain K37-3 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A2G8MXB6 |
| Locus tag | KZA81_RS15825 | Protein ID | WP_016715573.1 |
| Coordinates | 3388463..3388645 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | KZA81_RS15830 | Protein ID | WP_054904013.1 |
| Coordinates | 3388683..3389084 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZA81_RS15785 (KZA81_15695) | 3383909..3384070 | - | 162 | WP_177331322.1 | hypothetical protein | - |
| KZA81_RS15790 (KZA81_15700) | 3384067..3385755 | - | 1689 | WP_054904020.1 | terminase large subunit | - |
| KZA81_RS15795 (KZA81_15705) | 3385752..3386297 | - | 546 | WP_054904019.1 | terminase | - |
| KZA81_RS15800 (KZA81_15710) | 3386456..3386794 | - | 339 | WP_054904018.1 | HNH endonuclease signature motif containing protein | - |
| KZA81_RS15805 (KZA81_15715) | 3386964..3387194 | - | 231 | WP_054904017.1 | hypothetical protein | - |
| KZA81_RS15810 (KZA81_15720) | 3387210..3387440 | - | 231 | WP_054904016.1 | hypothetical protein | - |
| KZA81_RS15815 (KZA81_15725) | 3387488..3387805 | - | 318 | WP_054904041.1 | hypothetical protein | - |
| KZA81_RS15820 (KZA81_15730) | 3387805..3388176 | - | 372 | WP_054904015.1 | hypothetical protein | - |
| KZA81_RS15825 (KZA81_15735) | 3388463..3388645 | + | 183 | WP_016715573.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KZA81_RS15830 (KZA81_15740) | 3388683..3389084 | + | 402 | WP_054904013.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KZA81_RS15835 (KZA81_15745) | 3389189..3389578 | - | 390 | WP_054904012.1 | antiterminator Q family protein | - |
| KZA81_RS15840 (KZA81_15750) | 3389590..3389907 | - | 318 | WP_054904011.1 | hypothetical protein | - |
| KZA81_RS15845 (KZA81_15755) | 3389904..3390194 | - | 291 | WP_156357112.1 | hypothetical protein | - |
| KZA81_RS15850 (KZA81_15760) | 3390191..3391489 | - | 1299 | WP_260776812.1 | site-specific integrase | - |
| KZA81_RS15855 (KZA81_15765) | 3391486..3391914 | - | 429 | WP_260776814.1 | VRR-NUC domain-containing protein | - |
| KZA81_RS15860 (KZA81_15770) | 3391911..3392207 | - | 297 | WP_260776816.1 | DUF1364 domain-containing protein | - |
| KZA81_RS15865 | 3392204..3392338 | - | 135 | WP_260776818.1 | hypothetical protein | - |
| KZA81_RS15870 (KZA81_15775) | 3392335..3393114 | - | 780 | WP_260776820.1 | hypothetical protein | - |
| KZA81_RS15875 (KZA81_15780) | 3393101..3394081 | - | 981 | WP_260776822.1 | phage replication protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3359019..3409600 | 50581 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6696.86 Da Isoelectric Point: 11.2336
>T210358 WP_016715573.1 NZ_CP079903:3388463-3388645 [Pseudomonas juntendi]
VQSRQLIKELEAAGWVLKRVTGSHHIFKHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK
VQSRQLIKELEAAGWVLKRVTGSHHIFKHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK
Download Length: 183 bp
>T210358 NZ_CP104503:c3852770-3852432 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCAAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCAAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14528.38 Da Isoelectric Point: 4.1955
>AT210358 WP_054904013.1 NZ_CP079903:3388683-3389084 [Pseudomonas juntendi]
MQYPICIEWGDENTATGIQIPDIPGAVTAGDTFEEAYTSAVEVAHIMLEEIASNGQAIPMPTSAAAHRDNPDFADMGWGM
LEIDITPYLGKTEKVNVTLPGFVIQKIDQYVRDHNVKSRSSFLADAAMEKLGR
MQYPICIEWGDENTATGIQIPDIPGAVTAGDTFEEAYTSAVEVAHIMLEEIASNGQAIPMPTSAAAHRDNPDFADMGWGM
LEIDITPYLGKTEKVNVTLPGFVIQKIDQYVRDHNVKSRSSFLADAAMEKLGR
Download Length: 402 bp
>AT210358 NZ_CP104503:3852788-3852841 [Escherichia coli]
AATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|