Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 52006..52528 Replicon plasmid p5ZF15-2-1
Accession NZ_CP079893
Organism Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)


Gene name relE Uniprot ID U9YLU1
Locus tag KYD87_RS25195 Protein ID WP_000638823.1
Coordinates 52006..52287 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y7J1
Locus tag KYD87_RS25200 Protein ID WP_000121741.1
Coordinates 52277..52528 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYD87_RS25160 (KYD87_25020) 48155..48475 - 321 WP_000362080.1 VirB3 family type IV secretion system protein -
KYD87_RS25165 48546..48836 - 291 WP_000865479.1 conjugal transfer protein -
KYD87_RS25170 (KYD87_25030) 48836..49420 - 585 WP_001177113.1 lytic transglycosylase domain-containing protein -
KYD87_RS25175 (KYD87_25035) 49441..49839 - 399 WP_001153665.1 hypothetical protein -
KYD87_RS25180 (KYD87_25040) 49958..50395 - 438 WP_000539665.1 type IV pilus biogenesis protein PilM -
KYD87_RS25185 (KYD87_25045) 50401..51636 - 1236 WP_015059538.1 TcpQ domain-containing protein -
KYD87_RS25190 (KYD87_25050) 51639..51938 - 300 WP_000835764.1 TrbM/KikA/MpfK family conjugal transfer protein -
KYD87_RS25195 (KYD87_25055) 52006..52287 - 282 WP_000638823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYD87_RS25200 (KYD87_25060) 52277..52528 - 252 WP_000121741.1 hypothetical protein Antitoxin
KYD87_RS25205 (KYD87_25065) 52628..53263 - 636 WP_015059536.1 hypothetical protein -
KYD87_RS25210 (KYD87_25070) 53311..54102 + 792 WP_023154636.1 DUF5710 domain-containing protein -
KYD87_RS25215 (KYD87_25075) 54357..54581 - 225 WP_000713561.1 EexN family lipoprotein -
KYD87_RS25220 (KYD87_25080) 54590..55234 - 645 WP_001310442.1 type IV secretion system protein -
KYD87_RS25225 (KYD87_25085) 55240..56235 - 996 WP_001028541.1 type IV secretion system protein -
KYD87_RS25230 (KYD87_25090) 56239..56496 - 258 WP_000739144.1 hypothetical protein -
KYD87_RS25235 (KYD87_25095) 56493..56795 - 303 WP_001360345.1 hypothetical protein -
KYD87_RS25240 (KYD87_25100) 57066..57278 - 213 WP_039022940.1 hypothetical protein -
KYD87_RS25245 (KYD87_25105) 57289..57459 - 171 WP_000550720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 - 1..61228 61228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10945.79 Da        Isoelectric Point: 10.4997

>T210355 WP_000638823.1 NZ_CP079893:c52287-52006 [Escherichia fergusonii]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR

Download         Length: 282 bp

>T210355 NZ_CP104503:c2906186-2906079 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.38 Da        Isoelectric Point: 3.9823

>AT210355 WP_000121741.1 NZ_CP079893:c52528-52277 [Escherichia fergusonii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL

Download         Length: 252 bp

>AT210355 NZ_CP104503:2906243-2906298 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YLU1

Antitoxin

Source ID Structure
AlphaFold DB U9Y7J1

References