Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 8907..9499 | Replicon | plasmid p5ZF15-2-1 |
| Accession | NZ_CP079893 | ||
| Organism | Escherichia fergusonii strain 5zf15-2-1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1I9ZJC5 |
| Locus tag | KYD87_RS24970 | Protein ID | WP_000513532.1 |
| Coordinates | 8907..9155 (+) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A1I9ZJ49 |
| Locus tag | KYD87_RS24975 | Protein ID | WP_000681609.1 |
| Coordinates | 9152..9499 (+) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYD87_RS24930 (KYD87_24795) | 3911..4576 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| KYD87_RS24935 (KYD87_24800) | 5165..5494 | + | 330 | WP_000855119.1 | hypothetical protein | - |
| KYD87_RS24940 (KYD87_24805) | 5898..6413 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
| KYD87_RS24945 (KYD87_24810) | 6517..7059 | + | 543 | WP_001083904.1 | hypothetical protein | - |
| KYD87_RS24950 (KYD87_24815) | 7056..7310 | + | 255 | WP_001230709.1 | hypothetical protein | - |
| KYD87_RS24955 (KYD87_24820) | 7307..7549 | + | 243 | WP_000151456.1 | hypothetical protein | - |
| KYD87_RS24960 (KYD87_24825) | 7770..7988 | + | 219 | WP_154101533.1 | hypothetical protein | - |
| KYD87_RS24965 (KYD87_24830) | 8120..8413 | + | 294 | WP_000673428.1 | hypothetical protein | - |
| KYD87_RS24970 (KYD87_24835) | 8907..9155 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KYD87_RS24975 (KYD87_24840) | 9152..9499 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KYD87_RS24980 | 9587..10030 | - | 444 | WP_023223351.1 | hypothetical protein | - |
| KYD87_RS24985 (KYD87_24850) | 10271..10570 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KYD87_RS24990 (KYD87_24855) | 10830..11156 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| KYD87_RS24995 (KYD87_24860) | 11158..11481 | - | 324 | WP_223666488.1 | hypothetical protein | - |
| KYD87_RS25000 | 11458..11598 | - | 141 | Protein_20 | hypothetical protein | - |
| KYD87_RS25005 (KYD87_24865) | 11618..12325 | - | 708 | WP_000108794.1 | hypothetical protein | - |
| KYD87_RS25010 (KYD87_24870) | 12327..13079 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
| KYD87_RS25015 (KYD87_24875) | 13097..13498 | - | 402 | WP_021575837.1 | hypothetical protein | - |
| KYD87_RS25020 (KYD87_24880) | 13867..14208 | + | 342 | WP_000730722.1 | plasmid mobilization relaxosome protein MobC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61228 | 61228 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9378.03 Da Isoelectric Point: 10.4800
>T210354 WP_000513532.1 NZ_CP079893:8907-9155 [Escherichia fergusonii]
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
Download Length: 249 bp
>T210354 NZ_CP104503:2484773-2485237 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13206.97 Da Isoelectric Point: 4.8313
>AT210354 WP_000681609.1 NZ_CP079893:9152-9499 [Escherichia fergusonii]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA
Download Length: 348 bp
>AT210354 NZ_CP104503:2484438-2484773 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1I9ZJC5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1I9ZJ49 |