Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 7056..7549 | Replicon | plasmid p5ZF15-2-1 |
| Accession | NZ_CP079893 | ||
| Organism | Escherichia fergusonii strain 5zf15-2-1 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9Y9W8 |
| Locus tag | KYD87_RS24950 | Protein ID | WP_001230709.1 |
| Coordinates | 7056..7310 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | U9Y4R8 |
| Locus tag | KYD87_RS24955 | Protein ID | WP_000151456.1 |
| Coordinates | 7307..7549 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYD87_RS24910 | 2570..2722 | + | 153 | Protein_2 | FlmC family protein | - |
| KYD87_RS24915 (KYD87_24780) | 2670..2789 | + | 120 | WP_241215590.1 | Hok/Gef family protein | - |
| KYD87_RS24920 (KYD87_24785) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| KYD87_RS24925 (KYD87_24790) | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| KYD87_RS24930 (KYD87_24795) | 3911..4576 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| KYD87_RS24935 (KYD87_24800) | 5165..5494 | + | 330 | WP_000855119.1 | hypothetical protein | - |
| KYD87_RS24940 (KYD87_24805) | 5898..6413 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
| KYD87_RS24945 (KYD87_24810) | 6517..7059 | + | 543 | WP_001083904.1 | hypothetical protein | - |
| KYD87_RS24950 (KYD87_24815) | 7056..7310 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
| KYD87_RS24955 (KYD87_24820) | 7307..7549 | + | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
| KYD87_RS24960 (KYD87_24825) | 7770..7988 | + | 219 | WP_154101533.1 | hypothetical protein | - |
| KYD87_RS24965 (KYD87_24830) | 8120..8413 | + | 294 | WP_000673428.1 | hypothetical protein | - |
| KYD87_RS24970 (KYD87_24835) | 8907..9155 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
| KYD87_RS24975 (KYD87_24840) | 9152..9499 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KYD87_RS24980 | 9587..10030 | - | 444 | WP_023223351.1 | hypothetical protein | - |
| KYD87_RS24985 (KYD87_24850) | 10271..10570 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KYD87_RS24990 (KYD87_24855) | 10830..11156 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| KYD87_RS24995 (KYD87_24860) | 11158..11481 | - | 324 | WP_223666488.1 | hypothetical protein | - |
| KYD87_RS25000 | 11458..11598 | - | 141 | Protein_20 | hypothetical protein | - |
| KYD87_RS25005 (KYD87_24865) | 11618..12325 | - | 708 | WP_000108794.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61228 | 61228 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T210353 WP_001230709.1 NZ_CP079893:7056-7310 [Escherichia fergusonii]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T210353 NZ_CP104503:2269048-2269422 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT210353 WP_000151456.1 NZ_CP079893:7307-7549 [Escherichia fergusonii]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT210353 NZ_CP104503:2268590-2268958 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9H8F0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9GNF5 |