Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2432468..2433189 Replicon chromosome
Accession NZ_CP079891
Organism Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KYD87_RS12170 Protein ID WP_087835501.1
Coordinates 2432468..2432785 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KYD87_RS12175 Protein ID WP_117031222.1
Coordinates 2432824..2433189 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYD87_RS12140 (2427551) 2427551..2428423 + 873 WP_148047655.1 HNH endonuclease -
KYD87_RS12145 (2428488) 2428488..2428646 + 159 Protein_2385 peptidase -
KYD87_RS12150 (2428895) 2428895..2429230 - 336 WP_223666427.1 hypothetical protein -
KYD87_RS12160 (2430663) 2430663..2431226 - 564 WP_223666463.1 hypothetical protein -
KYD87_RS25555 (2431589) 2431589..2432164 - 576 WP_263300207.1 reverse transcriptase domain-containing protein -
KYD87_RS12170 (2432468) 2432468..2432785 - 318 WP_087835501.1 TA system toxin CbtA family protein Toxin
KYD87_RS12175 (2432824) 2432824..2433189 - 366 WP_117031222.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KYD87_RS12180 (2433215) 2433215..2433436 - 222 WP_087835505.1 DUF987 family protein -
KYD87_RS12185 (2433433) 2433433..2433975 - 543 WP_200007976.1 DNA repair protein RadC -
KYD87_RS12190 (2433988) 2433988..2434431 - 444 WP_087835508.1 antirestriction protein -
KYD87_RS12195 (2434462) 2434462..2435121 - 660 Protein_2395 DUF945 domain-containing protein -
KYD87_RS12200 (2435195) 2435195..2436363 + 1169 WP_181666549.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2427551..2447170 19619
- inside IScluster/Tn - - 2429323..2436363 7040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-103)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12152.96 Da        Isoelectric Point: 6.2150

>T210333 WP_087835501.1 NZ_CP079891:c2432785-2432468 [Escherichia fergusonii]
MQILSSQPTQAAQPCLSPVEIWQRLLTHLLLKHYGLALNDTPFSNETVIQEHIDAGITMANAMNFLVEKYELVRIDRREF
DWQEKSPYLQAVDILRARQATGMRQ

Download         Length: 318 bp

>T210333 NZ_CP104500:4003487-4003765 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13423.95 Da        Isoelectric Point: 4.7864

>AT210333 WP_117031222.1 NZ_CP079891:c2433189-2432824 [Escherichia fergusonii]
MNNHSESGTKPENPACQQWGLQSTITPCFGARLVQEGNRLHFLADRAGFNGAFSDDDALHLEQTFPLILKQLEMMLTSGE
LSPRHQHSVTLYHNGLSCEADTLGSCGYIYIAIYPDQTEPQ

Download         Length: 366 bp

>AT210333 NZ_CP104500:4003224-4003484 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References