Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2263936..2264771 Replicon chromosome
Accession NZ_CP079891
Organism Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KYD87_RS11490 Protein ID WP_001565141.1
Coordinates 2263936..2264313 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KYD87_RS11495 Protein ID WP_001565140.1
Coordinates 2264403..2264771 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYD87_RS11465 (2260009) 2260009..2260992 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
KYD87_RS11470 (2261803) 2261803..2261973 - 171 Protein_2249 IS110 family transposase -
KYD87_RS11475 (2262315) 2262315..2263157 - 843 WP_223666402.1 DUF4942 domain-containing protein -
KYD87_RS11480 (2263242) 2263242..2263439 - 198 WP_000839256.1 DUF957 domain-containing protein -
KYD87_RS11485 (2263451) 2263451..2263939 - 489 WP_001565142.1 DUF5983 family protein -
KYD87_RS11490 (2263936) 2263936..2264313 - 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
KYD87_RS11495 (2264403) 2264403..2264771 - 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KYD87_RS11500 (2264846) 2264846..2265067 - 222 WP_000692303.1 DUF987 domain-containing protein -
KYD87_RS11505 (2265136) 2265136..2265612 - 477 WP_194151990.1 RadC family protein -
KYD87_RS11510 (2265628) 2265628..2266113 - 486 WP_001565139.1 antirestriction protein -
KYD87_RS11515 (2266205) 2266205..2267023 - 819 WP_223666403.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T210331 WP_001565141.1 NZ_CP079891:c2264313-2263936 [Escherichia fergusonii]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T210331 NZ_CP104500:3789465-3789683 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT210331 WP_001565140.1 NZ_CP079891:c2264771-2264403 [Escherichia fergusonii]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210331 NZ_CP104500:3789065-3789439 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References