Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1842548..1843167 Replicon chromosome
Accession NZ_CP079891
Organism Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KYD87_RS09480 Protein ID WP_001280991.1
Coordinates 1842949..1843167 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag KYD87_RS09475 Protein ID WP_000344803.1
Coordinates 1842548..1842922 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYD87_RS09465 (1837680) 1837680..1838873 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KYD87_RS09470 (1838896) 1838896..1842045 + 3150 WP_001132493.1 efflux RND transporter permease AcrB -
KYD87_RS09475 (1842548) 1842548..1842922 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
KYD87_RS09480 (1842949) 1842949..1843167 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KYD87_RS09485 (1843664) 1843664..1844134 + 471 WP_002431406.1 YlaC family protein -
KYD87_RS09490 (1844273) 1844273..1845823 + 1551 WP_001260376.1 EAL domain-containing protein -
KYD87_RS09495 (1845865) 1845865..1846218 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KYD87_RS09500 (1846562) 1846562..1846789 - 228 WP_001572622.1 DUF2188 domain-containing protein -
KYD87_RS09505 (1847007) 1847007..1847627 - 621 WP_001572621.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T210328 WP_001280991.1 NZ_CP079891:1842949-1843167 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210328 NZ_CP104500:c2085363-2085256 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT210328 WP_000344803.1 NZ_CP079891:1842548-1842922 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT210328 NZ_CP104500:2085410-2085476 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References