Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1050604..1051439 Replicon chromosome
Accession NZ_CP079891
Organism Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6H2GFM1
Locus tag KYD87_RS05455 Protein ID WP_065304416.1
Coordinates 1050604..1050981 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6H2GGB7
Locus tag KYD87_RS05460 Protein ID WP_001285390.1
Coordinates 1051071..1051439 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYD87_RS05415 (1046045) 1046045..1046329 - 285 WP_032192671.1 hypothetical protein -
KYD87_RS05420 (1046424) 1046424..1046978 - 555 WP_111975902.1 hypothetical protein -
KYD87_RS05425 (1047345) 1047345..1047749 - 405 Protein_1077 PHP domain-containing protein -
KYD87_RS05430 (1047836) 1047836..1048774 - 939 WP_182211894.1 glyoxylate/hydroxypyruvate reductase GhrA -
KYD87_RS05440 (1049246) 1049246..1050088 - 843 WP_065304417.1 DUF4942 domain-containing protein -
KYD87_RS05445 (1050185) 1050185..1050382 - 198 WP_086598277.1 DUF957 domain-containing protein -
KYD87_RS05450 (1050458) 1050458..1050607 - 150 Protein_1081 DUF5983 family protein -
KYD87_RS05455 (1050604) 1050604..1050981 - 378 WP_065304416.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KYD87_RS05460 (1051071) 1051071..1051439 - 369 WP_001285390.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KYD87_RS05465 (1051489) 1051489..1052133 - 645 WP_065304415.1 antitoxin of toxin-antitoxin stability system -
KYD87_RS05470 (1052148) 1052148..1052369 - 222 WP_000692312.1 DUF987 domain-containing protein -
KYD87_RS05475 (1052438) 1052438..1052914 - 477 WP_001186747.1 RadC family protein -
KYD87_RS05480 (1052929) 1052929..1053414 - 486 WP_000214317.1 antirestriction protein -
KYD87_RS05485 (1053505) 1053505..1054326 - 822 WP_106668205.1 DUF932 domain-containing protein -
KYD87_RS05490 (1054547) 1054547..1054957 - 411 WP_000846713.1 hypothetical protein -
KYD87_RS05495 (1054973) 1054973..1055650 - 678 WP_059239983.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14060.06 Da        Isoelectric Point: 7.8522

>T210325 WP_065304416.1 NZ_CP079891:c1050981-1050604 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ

Download         Length: 378 bp

>T210325 NZ_CP104500:1937898-1938152 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.52 Da        Isoelectric Point: 5.9618

>AT210325 WP_001285390.1 NZ_CP079891:c1051439-1051071 [Escherichia fergusonii]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT210325 NZ_CP104500:1937650-1937901 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GFM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GGB7

References