Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 2264..2729 Replicon plasmid p6S41-1
Accession NZ_CP079887
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag KYC43_RS24160 Protein ID WP_001230707.1
Coordinates 2478..2729 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag KYC43_RS24155 Protein ID WP_000801440.1
Coordinates 2264..2491 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS24135 (KYC43_24020) 173..520 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
KYC43_RS24140 (KYC43_24025) 517..765 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
KYC43_RS24145 (KYC43_24030) 1070..1420 - 351 WP_000854259.1 hypothetical protein -
KYC43_RS24150 (KYC43_24035) 1511..1810 - 300 WP_000650309.1 hypothetical protein -
KYC43_RS24155 (KYC43_24040) 2264..2491 - 228 WP_000801440.1 hypothetical protein Antitoxin
KYC43_RS24160 (KYC43_24045) 2478..2729 - 252 WP_001230707.1 hypothetical protein Toxin
KYC43_RS24165 (KYC43_24050) 2726..3268 - 543 WP_001083906.1 hypothetical protein -
KYC43_RS24170 (KYC43_24055) 3373..3888 - 516 WP_001025395.1 J domain-containing protein -
KYC43_RS24175 (KYC43_24060) 4396..4668 + 273 WP_000019163.1 hypothetical protein -
KYC43_RS24180 (KYC43_24065) 4649..5815 + 1167 WP_223672119.1 IS91 family transposase -
KYC43_RS24185 (KYC43_24070) 6106..6294 + 189 WP_000957857.1 hypothetical protein -
KYC43_RS24190 (KYC43_24075) 6304..7503 + 1200 WP_000948429.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 / qnrS1 - 1..46394 46394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T210315 WP_001230707.1 NZ_CP079887:c2729-2478 [Escherichia fergusonii]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T210315 NZ_CP104498:1031031-1031444 [Ralstonia pseudosolanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT210315 WP_000801440.1 NZ_CP079887:c2491-2264 [Escherichia fergusonii]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT210315 NZ_CP104498:1030811-1031044 [Ralstonia pseudosolanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References