Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 173..765 Replicon plasmid p6S41-1
Accession NZ_CP079887
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag KYC43_RS24140 Protein ID WP_000520549.1
Coordinates 517..765 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag KYC43_RS24135 Protein ID WP_000681613.1
Coordinates 173..520 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS24135 (KYC43_24020) 173..520 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KYC43_RS24140 (KYC43_24025) 517..765 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
KYC43_RS24145 (KYC43_24030) 1070..1420 - 351 WP_000854259.1 hypothetical protein -
KYC43_RS24150 (KYC43_24035) 1511..1810 - 300 WP_000650309.1 hypothetical protein -
KYC43_RS24155 (KYC43_24040) 2264..2491 - 228 WP_000801440.1 hypothetical protein -
KYC43_RS24160 (KYC43_24045) 2478..2729 - 252 WP_001230707.1 hypothetical protein -
KYC43_RS24165 (KYC43_24050) 2726..3268 - 543 WP_001083906.1 hypothetical protein -
KYC43_RS24170 (KYC43_24055) 3373..3888 - 516 WP_001025395.1 J domain-containing protein -
KYC43_RS24175 (KYC43_24060) 4396..4668 + 273 WP_000019163.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 / qnrS1 - 1..46394 46394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T210314 WP_000520549.1 NZ_CP079887:c765-517 [Escherichia fergusonii]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T210314 NZ_CP104497:450212-450556 [Ralstonia pseudosolanacearum]
ATGGATGCTACCTTTATCGAGTTGCCGCCTTTTCAGAGGCTGCGGGAGCACTATCTCTCGGACGACGAGTACCGAGCGCT
CCAACAGGAACTGCTGGCCCGGCCGGACGCCGGCGACGTCATCAAGGGGACAGGTGGCCTACGCAAGCTGCGATTTTCGG
ACAAGCGGCGCGGCAAAGGTAAGCGCGGCGGTCTGCGCGTGATTGACTACCACTGGGATGGAGGCGGCCAATTCTGGATG
TTTGTCGTCTACGACAAGGGCGAGGCGGACGACCTTTCCAGCGACGAGCGCAAAGTGCTGGCACGGCTGTTGGAGCAGGA
AGTCAAGGCAAGGAGTGAGCGATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT210314 WP_000681613.1 NZ_CP079887:c520-173 [Escherichia fergusonii]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT210314 NZ_CP104497:450553-450864 [Ralstonia pseudosolanacearum]
ATGAAACGGAACCTGTTTGCTGAGTTGAAGGAGGGGATGGATGCGCTTGCCGCAGAGCGCGAAGGAAAGATGACCCTTCG
CAAGGTGAAGGTCCGCGTGCTCCAGCCGCTTGACGTGACAGCCGAAGAAATCAAGGCCGTTCGCGCAGCGGCACATGCTT
CACAGGCTGTCATGGCACGTCGACTGCGCGTCAATGTGCGCACCTACCAGAACTGGGAACAAGGAACCGCCAAACCGAAC
ACCCAGGCGGCTGTGTTGATCAAGCTCGTCGAGAAGCATCCGGAAACGTTGCAGATGCTGGAAGCGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References