Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 11846..12368 Replicon plasmid p2-6S41-1
Accession NZ_CP079886
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag KYC43_RS23845 Protein ID WP_000220560.1
Coordinates 11846..12127 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KYC43_RS23850 Protein ID WP_000121743.1
Coordinates 12117..12368 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS23805 (KYC43_23695) 7136..7219 + 84 WP_000565612.1 damage-inducible type I toxin DinQ -
KYC43_RS23810 (KYC43_23700) 7374..8018 - 645 WP_000203396.1 recombinase family protein -
KYC43_RS23815 (KYC43_23705) 8223..8411 + 189 WP_000957857.1 hypothetical protein -
KYC43_RS23820 (KYC43_23710) 8421..9620 + 1200 WP_000948429.1 IS91 family transposase -
KYC43_RS23825 (KYC43_23715) 9793..10233 - 441 Protein_13 IS6-like element IS26 family transposase -
KYC43_RS23830 (KYC43_23720) 10288..10386 + 99 Protein_14 IS200/IS605 family transposase -
KYC43_RS23835 (KYC43_23725) 10578..10772 - 195 WP_053273080.1 hypothetical protein -
KYC43_RS23845 (KYC43_23735) 11846..12127 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYC43_RS23850 (KYC43_23740) 12117..12368 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KYC43_RS23855 (KYC43_23745) 13525..14361 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
KYC43_RS23860 (KYC43_23750) 14401..14847 + 447 Protein_20 hypothetical protein -
KYC43_RS23865 (KYC43_23755) 14984..15340 + 357 WP_000456533.1 DNA distortion polypeptide 3 -
KYC43_RS23870 15337..15897 - 561 WP_223672116.1 hypothetical protein -
KYC43_RS23875 15866..16315 - 450 WP_223672117.1 hypothetical protein -
KYC43_RS23880 (KYC43_23765) 16340..16621 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(3)-IId / floR - 1..66077 66077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T210313 WP_000220560.1 NZ_CP079886:c12127-11846 [Escherichia fergusonii]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T210313 NZ_CP104496:c2495163-2493826 [Ralstonia pseudosolanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGGTTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGATCGCATCGACAGCGAGCCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCACGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTAGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCGGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT210313 WP_000121743.1 NZ_CP079886:c12368-12117 [Escherichia fergusonii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT210313 NZ_CP104496:c2495421-2495167 [Ralstonia pseudosolanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGCTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAGTTGGGCGCACTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTACTGCGCATCCTGCACGCGCTCGGCGCGCAGTTGACGCTGCGCACGTCCGCGCCCGCCGGCACCCCCTCCGCCGCG
CCCGCCGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References