Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 350617..351176 Replicon chromosome
Accession NC_005140
Organism Vibrio vulnificus YJ016

Toxin (Protein)


Gene name relE Uniprot ID Q7MFK6
Locus tag BJE04_RS17280 Protein ID WP_011151716.1
Coordinates 350898..351176 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3Q0L0M2
Locus tag BJE04_RS17275 Protein ID WP_011082348.1
Coordinates 350617..350901 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJE04_RS17240 345665..346690 + 1026 WP_196763494.1 L-threonine 3-dehydrogenase -
BJE04_RS17245 346762..347190 - 429 WP_038939949.1 hypothetical protein -
BJE04_RS17250 347285..347695 - 411 WP_110097104.1 hypothetical protein -
BJE04_RS17255 348096..348596 - 501 WP_011151711.1 hypothetical protein -
BJE04_RS17260 348674..348937 - 264 WP_043877449.1 hypothetical protein -
BJE04_RS17265 349123..349656 - 534 WP_011151713.1 hypothetical protein -
BJE04_RS17270 349791..350399 - 609 WP_011151714.1 hypothetical protein -
BJE04_RS17275 350617..350901 + 285 WP_011082348.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BJE04_RS17280 350898..351176 + 279 WP_011151716.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BJE04_RS24620 351205..351294 - 90 WP_080505766.1 DUF3265 domain-containing protein -
BJE04_RS17285 351323..352339 - 1017 WP_011151717.1 RelA/SpoT domain-containing protein -
BJE04_RS17290 352550..353017 - 468 WP_011151718.1 hypothetical protein -
BJE04_RS24995 353471..353719 - 249 WP_146209474.1 hypothetical protein -
BJE04_RS17295 353952..354539 - 588 WP_011151719.1 DUF1471 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10872.53 Da        Isoelectric Point: 4.3423

>T21031 WP_011151716.1 NC_005140:350898-351176 [Vibrio vulnificus YJ016]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIHGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T21031 NC_005140:350898-351176 [Vibrio vulnificus YJ016]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAATCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCACGGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT21031 WP_011082348.1 NC_005140:350617-350901 [Vibrio vulnificus YJ016]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT21031 NC_005140:350617-350901 [Vibrio vulnificus YJ016]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7MFK6

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L0M2

References