Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1877487..1878032 | Replicon | chromosome |
| Accession | NC_005139 | ||
| Organism | Vibrio vulnificus YJ016 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q7MKD5 |
| Locus tag | BJE04_RS09040 | Protein ID | WP_011150434.1 |
| Coordinates | 1877736..1878032 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7MKD6 |
| Locus tag | BJE04_RS09035 | Protein ID | WP_000557294.1 |
| Coordinates | 1877487..1877729 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BJE04_RS09005 | 1872559..1872762 | - | 204 | WP_011150427.1 | hypothetical protein | - |
| BJE04_RS24125 | 1872813..1872905 | - | 93 | WP_193343208.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09015 | 1873170..1873409 | - | 240 | WP_181392305.1 | hypothetical protein | - |
| BJE04_RS24130 | 1873450..1873596 | - | 147 | WP_080505671.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09020 | 1874063..1874569 | - | 507 | WP_011150429.1 | DUF2199 domain-containing protein | - |
| BJE04_RS24140 | 1874598..1874690 | - | 93 | WP_079858050.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09025 | 1874711..1875820 | - | 1110 | WP_011150430.1 | hypothetical protein | - |
| BJE04_RS24145 | 1875817..1875993 | - | 177 | WP_080505673.1 | DUF3265 domain-containing protein | - |
| BJE04_RS24150 | 1876307..1876474 | - | 168 | WP_011150431.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09030 | 1876447..1876776 | - | 330 | WP_013571675.1 | hypothetical protein | - |
| BJE04_RS24155 | 1876769..1876957 | - | 189 | WP_181392306.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09035 | 1877487..1877729 | + | 243 | WP_000557294.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| BJE04_RS09040 | 1877736..1878032 | + | 297 | WP_011150434.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BJE04_RS09045 | 1878203..1878691 | - | 489 | WP_043877202.1 | hypothetical protein | - |
| BJE04_RS24165 | 1878718..1878852 | - | 135 | WP_080505675.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09050 | 1879234..1880127 | - | 894 | WP_155116715.1 | IS3 family transposase | - |
| BJE04_RS09055 | 1880169..1880390 | - | 222 | Protein_1776 | transposase | - |
| BJE04_RS24175 | 1880970..1881089 | - | 120 | WP_080505728.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09060 | 1881556..1881873 | - | 318 | WP_011150436.1 | hypothetical protein | - |
| BJE04_RS24180 | 1881827..1882039 | - | 213 | WP_080505677.1 | DUF3265 domain-containing protein | - |
| BJE04_RS24185 | 1882381..1882476 | - | 96 | WP_080505678.1 | DUF3265 domain-containing protein | - |
| BJE04_RS09065 | 1882513..1882908 | - | 396 | WP_043877203.1 | cell envelope integrity protein TolA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1788930..1930904 | 141974 | |
| - | inside | Integron | - | - | 1823810..1930904 | 107094 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11205.93 Da Isoelectric Point: 10.0229
>T21030 WP_011150434.1 NC_005139:1877736-1878032 [Vibrio vulnificus YJ016]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEGG
FILVVAILGQSQLPQNHL
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEGG
FILVVAILGQSQLPQNHL
Download Length: 297 bp
>T21030 NC_005139:1877736-1878032 [Vibrio vulnificus YJ016]
ATGCAAAAGAACAAATACAAACTGAGTAAATTAGCTCAGGCTCATTTACGGAAAATTAAAAGCTATACAGTTAACAATTT
CTCCGAGATGCAGTGGCGAAGCTATAAAGATACGTTACTAACTGGTTTTCAAATGCTTGCTGATAATCCAGCTGTTGGTC
GCAGTTGTGATGAAATATACCCAAGTGGATTCTATTTCCCTGTAGGCAAGCATACTGCTTACTTTACAAAAGAGGGTGGC
TTCATTTTAGTTGTAGCTATACTCGGTCAATCACAGCTCCCTCAGAACCACTTATAG
ATGCAAAAGAACAAATACAAACTGAGTAAATTAGCTCAGGCTCATTTACGGAAAATTAAAAGCTATACAGTTAACAATTT
CTCCGAGATGCAGTGGCGAAGCTATAAAGATACGTTACTAACTGGTTTTCAAATGCTTGCTGATAATCCAGCTGTTGGTC
GCAGTTGTGATGAAATATACCCAAGTGGATTCTATTTCCCTGTAGGCAAGCATACTGCTTACTTTACAAAAGAGGGTGGC
TTCATTTTAGTTGTAGCTATACTCGGTCAATCACAGCTCCCTCAGAACCACTTATAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8973.13 Da Isoelectric Point: 4.6135
>AT21030 WP_000557294.1 NC_005139:1877487-1877729 [Vibrio vulnificus YJ016]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLRHCFESAKQDLAQGDVVDGEDFLNAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLRHCFESAKQDLAQGDVVDGEDFLNAL
Download Length: 243 bp
>AT21030 NC_005139:1877487-1877729 [Vibrio vulnificus YJ016]
ATGCATACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGCTACTCCTAAGCGCCCAACGTGAGCCTGTGAAGAT
TAGCAAGAACAGTAAAGATGCCGTAGTTGTAATGTCTATCAAAGACTATGAAGAGCTAGAAGCAATGAAGGCCGATTACC
TTAGACATTGCTTCGAGTCCGCAAAACAAGACTTAGCACAAGGTGATGTGGTTGATGGTGAAGACTTTTTGAATGCCTTA
TAA
ATGCATACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGCTACTCCTAAGCGCCCAACGTGAGCCTGTGAAGAT
TAGCAAGAACAGTAAAGATGCCGTAGTTGTAATGTCTATCAAAGACTATGAAGAGCTAGAAGCAATGAAGGCCGATTACC
TTAGACATTGCTTCGAGTCCGCAAAACAAGACTTAGCACAAGGTGATGTGGTTGATGGTGAAGACTTTTTGAATGCCTTA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|