Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3998193..3999029 | Replicon | chromosome |
| Accession | NZ_CP079884 | ||
| Organism | Escherichia fergusonii strain 6S41-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | KYC43_RS19495 | Protein ID | WP_001559913.1 |
| Coordinates | 3998193..3998570 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NQ68 |
| Locus tag | KYC43_RS19500 | Protein ID | WP_001540478.1 |
| Coordinates | 3998661..3999029 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYC43_RS19460 (3993235) | 3993235..3993477 | + | 243 | Protein_3802 | N-acetylneuraminic acid mutarotase | - |
| KYC43_RS19465 (3993551) | 3993551..3994423 | + | 873 | WP_148047655.1 | HNH endonuclease | - |
| KYC43_RS19470 (3994488) | 3994488..3994646 | + | 159 | Protein_3804 | peptidase | - |
| KYC43_RS19475 (3995387) | 3995387..3996489 | + | 1103 | Protein_3805 | IS3 family transposase | - |
| KYC43_RS24585 (3996768) | 3996768..3996890 | - | 123 | WP_263300258.1 | hypothetical protein | - |
| KYC43_RS19480 (3997257) | 3997257..3997406 | - | 150 | Protein_3807 | hypothetical protein | - |
| KYC43_RS19485 (3997491) | 3997491..3997688 | - | 198 | WP_021581277.1 | DUF957 domain-containing protein | - |
| KYC43_RS19490 (3997708) | 3997708..3998196 | - | 489 | WP_001559914.1 | DUF5983 family protein | - |
| KYC43_RS19495 (3998193) | 3998193..3998570 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| KYC43_RS19500 (3998661) | 3998661..3999029 | - | 369 | WP_001540478.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KYC43_RS19505 (3999186) | 3999186..3999407 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| KYC43_RS19510 (3999476) | 3999476..3999952 | - | 477 | WP_032186123.1 | RadC family protein | - |
| KYC43_RS19515 (3999968) | 3999968..4000453 | - | 486 | WP_000214414.1 | antirestriction protein | - |
| KYC43_RS19520 (4000545) | 4000545..4001363 | - | 819 | WP_001234749.1 | DUF932 domain-containing protein | - |
| KYC43_RS19525 (4001454) | 4001454..4001687 | - | 234 | WP_001117568.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3989537..4008590 | 19053 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T210299 WP_001559913.1 NZ_CP079884:c3998570-3998193 [Escherichia fergusonii]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T210299 NZ_CP104491:851397-851795 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13652.53 Da Isoelectric Point: 7.8398
>AT210299 WP_001540478.1 NZ_CP079884:c3999029-3998661 [Escherichia fergusonii]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT210299 NZ_CP104491:851170-851397 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NQ68 |