Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3556628..3557462 | Replicon | chromosome |
| Accession | NZ_CP079884 | ||
| Organism | Escherichia fergusonii strain 6S41-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2X7CAN1 |
| Locus tag | KYC43_RS17535 | Protein ID | WP_039025883.1 |
| Coordinates | 3556628..3557005 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2X5LBZ2 |
| Locus tag | KYC43_RS17540 | Protein ID | WP_039025882.1 |
| Coordinates | 3557094..3557462 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYC43_RS17510 (3551978) | 3551978..3553192 | - | 1215 | WP_001529718.1 | tyrosine-type recombinase/integrase | - |
| KYC43_RS17515 (3553569) | 3553569..3554888 | + | 1320 | WP_105284452.1 | site-specific integrase | - |
| KYC43_RS17520 (3554981) | 3554981..3555829 | - | 849 | WP_039025884.1 | DUF4942 domain-containing protein | - |
| KYC43_RS17525 (3555926) | 3555926..3556123 | - | 198 | WP_000772024.1 | DUF957 domain-containing protein | - |
| KYC43_RS17530 (3556143) | 3556143..3556631 | - | 489 | Protein_3422 | DUF5983 family protein | - |
| KYC43_RS17535 (3556628) | 3556628..3557005 | - | 378 | WP_039025883.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| KYC43_RS17540 (3557094) | 3557094..3557462 | - | 369 | WP_039025882.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KYC43_RS17545 (3557512) | 3557512..3558156 | - | 645 | WP_039025881.1 | hypothetical protein | - |
| KYC43_RS17550 (3558171) | 3558171..3558392 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| KYC43_RS17555 (3558461) | 3558461..3558937 | - | 477 | WP_001186745.1 | RadC family protein | - |
| KYC43_RS17560 (3558952) | 3558952..3559437 | - | 486 | WP_000214316.1 | antirestriction protein | - |
| KYC43_RS17565 (3559528) | 3559528..3560346 | - | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fdeC | 3533002..3575250 | 42248 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14176.22 Da Isoelectric Point: 7.8523
>T210295 WP_039025883.1 NZ_CP079884:c3557005-3556628 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T210295 NZ_CP104488:4613386-4613697 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13792.52 Da Isoelectric Point: 5.9582
>AT210295 WP_039025882.1 NZ_CP079884:c3557462-3557094 [Escherichia fergusonii]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT210295 NZ_CP104488:4613694-4614140 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X7CAN1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X5LBZ2 |