Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3403135..3403754 Replicon chromosome
Accession NZ_CP079884
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KYC43_RS16765 Protein ID WP_001280991.1
Coordinates 3403536..3403754 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag KYC43_RS16760 Protein ID WP_000344803.1
Coordinates 3403135..3403509 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS16750 (3398267) 3398267..3399460 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KYC43_RS16755 (3399483) 3399483..3402632 + 3150 WP_001132493.1 efflux RND transporter permease AcrB -
KYC43_RS16760 (3403135) 3403135..3403509 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
KYC43_RS16765 (3403536) 3403536..3403754 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KYC43_RS16770 (3404251) 3404251..3404721 + 471 WP_002431406.1 YlaC family protein -
KYC43_RS16775 (3404860) 3404860..3406410 + 1551 WP_001260376.1 EAL domain-containing protein -
KYC43_RS16780 (3406452) 3406452..3406805 - 354 WP_223671681.1 DUF1428 family protein -
KYC43_RS16790 (3407184) 3407184..3407495 + 312 WP_000409911.1 MGMT family protein -
KYC43_RS16795 (3407526) 3407526..3408098 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T210294 WP_001280991.1 NZ_CP079884:3403536-3403754 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210294 NZ_CP104488:c4612153-4611842 [Salmonella enterica]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGCAGTGGCGTACGAATTATCTATTTTCATCGTAGTCAACGGTATGAGGTTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT210294 WP_000344803.1 NZ_CP079884:3403135-3403509 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT210294 NZ_CP104488:c4611841-4611551 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References