Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1834069..1834585 Replicon chromosome
Accession NC_005139
Organism Vibrio vulnificus YJ016

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag BJE04_RS08780 Protein ID WP_005464459.1
Coordinates 1834069..1834338 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U2ZH00
Locus tag BJE04_RS08785 Protein ID WP_005526636.1
Coordinates 1834331..1834585 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJE04_RS08755 1829434..1830420 - 987 WP_011150370.1 hypothetical protein -
BJE04_RS08760 1830490..1831383 - 894 WP_155116715.1 IS3 family transposase -
BJE04_RS08765 1831425..1831646 - 222 Protein_1672 transposase -
BJE04_RS23860 1831657..1831875 - 219 WP_080505651.1 DUF3265 domain-containing protein -
BJE04_RS23870 1832182..1832289 - 108 WP_080505712.1 DUF3265 domain-containing protein -
BJE04_RS08770 1832296..1832910 - 615 WP_080505653.1 DUF3265 domain-containing protein -
BJE04_RS08775 1832920..1833426 - 507 WP_011150373.1 GNAT family N-acetyltransferase -
BJE04_RS25320 1833410..1833538 - 129 WP_080505654.1 DUF3265 domain-containing protein -
BJE04_RS08780 1834069..1834338 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
BJE04_RS08785 1834331..1834585 - 255 WP_005526636.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BJE04_RS24875 1834677..1834799 - 123 WP_110097236.1 DUF3265 domain-containing protein -
BJE04_RS23890 1835608..1835721 - 114 WP_080505713.1 DUF3265 domain-containing protein -
BJE04_RS08790 1835718..1836038 - 321 WP_043877189.1 hypothetical protein -
BJE04_RS23900 1836529..1836720 - 192 WP_011150376.1 DUF3265 domain-containing protein -
BJE04_RS08800 1836749..1837069 - 321 WP_029797024.1 DUF2834 domain-containing protein -
BJE04_RS23905 1837103..1837240 - 138 WP_080505714.1 DUF3265 domain-containing protein -
BJE04_RS08805 1837222..1837701 - 480 WP_011150378.1 GNAT family N-acetyltransferase -
BJE04_RS23910 1837726..1837848 - 123 WP_181392308.1 DUF3265 domain-containing protein -
BJE04_RS23915 1838488..1838610 - 123 Protein_1688 DUF3265 domain-containing protein -
BJE04_RS23920 1838972..1839061 - 90 WP_193343216.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1788930..1930904 141974
- inside Integron - - 1823810..1930904 107094


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T21029 WP_005464459.1 NC_005139:c1834338-1834069 [Vibrio vulnificus YJ016]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T21029 NC_005139:c1834338-1834069 [Vibrio vulnificus YJ016]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATGTTAAGCGCTCCCCATTTGAGGGCATCGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGCTTTTGGTCTCGTCGTATTGATGACACTAATCGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 5.0623

>AT21029 WP_005526636.1 NC_005139:c1834585-1834331 [Vibrio vulnificus YJ016]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT21029 NC_005139:c1834585-1834331 [Vibrio vulnificus YJ016]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGCCGCGATTCTGAAGATGCTGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A244CM06

References