Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1395331..1395956 Replicon chromosome
Accession NZ_CP079884
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag KYC43_RS06700 Protein ID WP_000911329.1
Coordinates 1395558..1395956 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KYC43_RS06695 Protein ID WP_000450524.1
Coordinates 1395331..1395558 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS06670 (1391132) 1391132..1391602 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
KYC43_RS06675 (1391602) 1391602..1392174 - 573 WP_182211927.1 glycine cleavage system transcriptional repressor -
KYC43_RS06680 (1392321) 1392321..1393199 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
KYC43_RS06685 (1393216) 1393216..1394250 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
KYC43_RS06690 (1394463) 1394463..1395176 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KYC43_RS06695 (1395331) 1395331..1395558 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KYC43_RS06700 (1395558) 1395558..1395956 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
KYC43_RS06705 (1396103) 1396103..1396966 + 864 WP_001267498.1 neutral zinc metallopeptidase -
KYC43_RS06710 (1396981) 1396981..1398996 + 2016 WP_182211926.1 tRNA cytosine(34) acetyltransferase TmcA -
KYC43_RS06715 (1399070) 1399070..1399768 + 699 WP_000679812.1 esterase -
KYC43_RS06720 (1399861) 1399861..1400061 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T210283 WP_000911329.1 NZ_CP079884:1395558-1395956 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T210283 NZ_CP104484:4774373-4774684 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT210283 WP_000450524.1 NZ_CP079884:1395331-1395558 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT210283 NZ_CP104484:4774681-4775127 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References