Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 718336..718886 Replicon chromosome
Accession NZ_CP079884
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag KYC43_RS03520 Protein ID WP_001160963.1
Coordinates 718572..718886 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag KYC43_RS03515 Protein ID WP_000125566.1
Coordinates 718336..718569 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS03490 (713408) 713408..713695 + 288 WP_001596509.1 ferredoxin-like protein FixX -
KYC43_RS03495 (713754) 713754..715085 + 1332 WP_182210693.1 MFS transporter -
KYC43_RS03500 (715193) 715193..715723 + 531 WP_032183187.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
KYC43_RS03505 (715716) 715716..717578 + 1863 WP_104918214.1 glutathione-regulated potassium-efflux system protein KefC -
KYC43_RS03510 (717771) 717771..718250 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
KYC43_RS03515 (718336) 718336..718569 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KYC43_RS03520 (718572) 718572..718886 + 315 WP_001160963.1 CcdB family protein Toxin
KYC43_RS03525 (718883) 718883..719731 - 849 WP_223671946.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
KYC43_RS03530 (719738) 719738..720115 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
KYC43_RS03535 (720118) 720118..720939 - 822 WP_046081975.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
KYC43_RS03540 (720936) 720936..721925 - 990 WP_000241247.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
KYC43_RS03545 (721925) 721925..723211 - 1287 WP_000800490.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T210278 WP_001160963.1 NZ_CP079884:718572-718886 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T210278 NZ_CP104484:3697852-3698127 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT210278 WP_000125566.1 NZ_CP079884:718336-718569 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT210278 NZ_CP104484:c3698117-3697695 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References