Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3846331..3847030 Replicon chromosome
Accession NZ_CP079882
Organism Proteus terrae strain 20Q172tw

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KZA80_RS17950 Protein ID WP_159364182.1
Coordinates 3846331..3846717 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KZA80_RS17955 Protein ID WP_075671318.1
Coordinates 3846710..3847030 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZA80_RS17935 (KZA80_17895) 3842369..3842953 - 585 WP_075671324.1 DNA-3-methyladenine glycosylase I -
KZA80_RS17940 (KZA80_17900) 3843192..3844097 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
KZA80_RS17945 (KZA80_17905) 3844107..3846179 + 2073 WP_075671322.1 glycine--tRNA ligase subunit beta -
KZA80_RS17950 (KZA80_17910) 3846331..3846717 + 387 WP_159364182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZA80_RS17955 (KZA80_17915) 3846710..3847030 + 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
KZA80_RS17960 (KZA80_17920) 3847097..3847417 - 321 WP_260797566.1 hypothetical protein -
KZA80_RS17965 (KZA80_17925) 3847523..3848809 - 1287 WP_075671314.1 DUF3748 domain-containing protein -
KZA80_RS17970 (KZA80_17930) 3848946..3849563 + 618 WP_006534609.1 trimeric intracellular cation channel family protein -
KZA80_RS17975 (KZA80_17935) 3849869..3850492 + 624 WP_006534608.1 guanylate kinase -
KZA80_RS17980 (KZA80_17940) 3850547..3850822 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14388.78 Da        Isoelectric Point: 10.0463

>T210272 WP_159364182.1 NZ_CP079882:3846331-3846717 [Proteus terrae]
MVIYKTKMFKNSFKKMPINDATLIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 387 bp

>T210272 NZ_CP104484:870437-870850 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT210272 WP_075671318.1 NZ_CP079882:3846710-3847030 [Proteus terrae]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT210272 NZ_CP104484:870190-870456 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References