Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3424060..3425782 | Replicon | chromosome |
| Accession | NZ_CP079882 | ||
| Organism | Proteus terrae strain 20Q172tw | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | KZA80_RS16180 | Protein ID | WP_170355928.1 |
| Coordinates | 3424060..3424998 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | KZA80_RS16185 | Protein ID | WP_170355935.1 |
| Coordinates | 3425006..3425782 (-) | Length | 259 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZA80_RS16160 (KZA80_16130) | 3420001..3420513 | - | 513 | WP_170355924.1 | S26 family signal peptidase | - |
| KZA80_RS16165 (KZA80_16135) | 3420497..3420844 | - | 348 | WP_156734078.1 | plasmid-related protein | - |
| KZA80_RS16170 (KZA80_16140) | 3420837..3423236 | - | 2400 | WP_170355926.1 | type IV secretion system protein TraC | - |
| KZA80_RS16175 (KZA80_16145) | 3423236..3423928 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| KZA80_RS16180 (KZA80_16150) | 3424060..3424998 | - | 939 | WP_170355928.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KZA80_RS16185 (KZA80_16155) | 3425006..3425782 | - | 777 | WP_170355935.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KZA80_RS16190 (KZA80_16160) | 3426002..3426388 | - | 387 | WP_000180225.1 | TraA family conjugative transfer protein | - |
| KZA80_RS16195 (KZA80_16165) | 3426385..3426957 | - | 573 | WP_001944091.1 | type IV conjugative transfer system lipoprotein TraV | - |
| KZA80_RS16200 (KZA80_16170) | 3427032..3428321 | - | 1290 | WP_170383165.1 | TraB/VirB10 family protein | - |
| KZA80_RS16205 (KZA80_16175) | 3428324..3429220 | - | 897 | WP_170355937.1 | type-F conjugative transfer system secretin TraK | - |
| KZA80_RS16210 (KZA80_16180) | 3429204..3429830 | - | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| KZA80_RS16215 (KZA80_16185) | 3429827..3430108 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(H) / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-VIa / floR | - | 3312300..3492243 | 179943 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35664.00 Da Isoelectric Point: 5.2653
>T210270 WP_170355928.1 NZ_CP079882:c3424998-3424060 [Proteus terrae]
MDKYSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYRNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKYSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYRNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T210270 NZ_CP104484:316725-317093 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
Antitoxin
Download Length: 259 a.a. Molecular weight: 29578.97 Da Isoelectric Point: 9.3775
>AT210270 WP_170355935.1 NZ_CP079882:c3425782-3425006 [Proteus terrae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKRG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKRG
Download Length: 777 bp
>AT210270 NZ_CP104484:316507-316728 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|