Detailed information of TA system TA210268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1089947..1090440
• Replicon: chromosome
• Accession: NZ_CP079880
• Organism: Enterococcus lactis strain CX 2-6_2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A133MTG0
• Locus tag: KU781_RS05325
• Protein ID: WP_002329323.1
• Coordinates: 1090174..1090440 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A829AAJ0
• Locus tag: KU781_RS05320
• Protein ID: WP_002329324.1
• Coordinates: 1089947..1090177 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU781_RS05290 (KU781_05290)	1084951..1085718	+	768	WP_002329331.1	MurR/RpiR family transcriptional regulator	-
KU781_RS05295 (KU781_05295)	1085719..1086162	+	444	WP_002329330.1	hypothetical protein	-
KU781_RS05300 (KU781_05300)	1086334..1086962	-	629	Protein_1051	glutamine amidotransferase	-
KU781_RS05305 (KU781_05305)	1087609..1088568	-	960	WP_002329328.1	IS30-like element IS6770 family transposase	-
KU781_RS05310 (KU781_05310)	1088818..1089123	+	306	WP_142666937.1	hypothetical protein	-
KU781_RS05315 (KU781_05315)	1089136..1089471	+	336	WP_002329326.1	hypothetical protein	-
KU781_RS05320 (KU781_05320)	1089947..1090177	+	231	WP_002329324.1	DUF6290 family protein	Antitoxin
KU781_RS05325 (KU781_05325)	1090174..1090440	+	267	WP_002329323.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KU781_RS05330 (KU781_05330)	1090692..1090919	+	228	WP_002329322.1	hypothetical protein	-
KU781_RS05335 (KU781_05335)	1090935..1092101	+	1167	WP_002329321.1	radical SAM family heme chaperone HemW	-
KU781_RS05340 (KU781_05340)	1092334..1093377	+	1044	WP_002329320.1	heat-inducible transcriptional repressor HrcA	-
KU781_RS05345 (KU781_05345)	1093471..1094034	+	564	WP_002292135.1	nucleotide exchange factor GrpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1087609..1088568	959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10617.27 Da
• Isoelectric Point: 10.1925

>T210268 WP_002329323.1 NZ_CP079880:1090174-1090440 [Enterococcus lactis]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Nucleotide

• Length: 267 bp

>T210268 NZ_CP104482:4606333-4606644 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8863.97 Da
• Isoelectric Point: 4.1938

>AT210268 WP_002329324.1 NZ_CP079880:1089947-1090177 [Enterococcus lactis]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Nucleotide

• Length: 231 bp

>AT210268 NZ_CP104482:4606641-4607087 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A133MTG0

Antitoxin

• AlphaFold DB: A0A829AAJ0