Detailed information of TA system TA210267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 9747..10273
• Replicon: plasmid pSMC-4_1
• Accession: NZ_CP079870
• Organism: Mycobacterium sp. SMC-4

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: KXD98_RS26735
• Protein ID: WP_260758395.1
• Coordinates: 9971..10273 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: -
• Locus tag: KXD98_RS26730
• Protein ID: WP_260758393.1
• Coordinates: 9747..9974 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXD98_RS26710 (KXD98_26570)	5367..5945	-	579	WP_260758390.1	hypothetical protein	-
KXD98_RS26715 (KXD98_26575)	6031..6783	-	753	WP_260758510.1	hypothetical protein	-
KXD98_RS26720 (KXD98_26580)	7095..7616	-	522	WP_260758391.1	hypothetical protein	-
KXD98_RS26725 (KXD98_26585)	7609..8325	-	717	WP_046361761.1	ParA family protein	-
KXD98_RS26730 (KXD98_26590)	9747..9974	+	228	WP_260758393.1	ribbon-helix-helix protein, CopG family	Antitoxin
KXD98_RS26735 (KXD98_26595)	9971..10273	+	303	WP_260758395.1	toxin	Toxin
KXD98_RS26740 (KXD98_26600)	10389..12395	-	2007	WP_260758397.1	hypothetical protein	-
KXD98_RS26745 (KXD98_26605)	12726..13013	-	288	WP_260758398.1	toxin-antitoxin system	-
KXD98_RS26750 (KXD98_26610)	13154..13480	+	327	WP_260758400.1	type VII secretion target	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..134412	134412

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10362.00 Da
• Isoelectric Point: 4.6062

>T210267 WP_260758395.1 NZ_CP079870:9971-10273 [Mycobacterium sp. SMC-4]
VIAPGDIAPRRDTSHEVYVVVLSNSIHLAADTGRVIACPFIPGKIPDAAMAFVVRVGQPEGVALPELVQWLPAAALDEPI
GNIGANALRDTASLVTALVT

Nucleotide

• Length: 303 bp

>T210267 NZ_CP104482:c4605100-4604789 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8185.28 Da
• Isoelectric Point: 5.6208

>AT210267 WP_260758393.1 NZ_CP079870:9747-9974 [Mycobacterium sp. SMC-4]
MAKDKVSITLDQDVLAAADADAKAAGLNRSELVEQALRHEHLRIALKSYMTTTVPALDIDDYAQKIYQANRASGL

Nucleotide

• Length: 228 bp

>AT210267 NZ_CP104482:c4604788-4604498 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA