Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4129128..4129687 Replicon chromosome
Accession NZ_CP079869
Organism Mycobacterium sp. SMC-4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KXD98_RS19520 Protein ID WP_260759969.1
Coordinates 4129128..4129496 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KXD98_RS19525 Protein ID WP_260759970.1
Coordinates 4129493..4129687 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD98_RS19485 (KXD98_19390) 4124974..4125762 + 789 WP_260759963.1 adenylate/guanylate cyclase domain-containing protein -
KXD98_RS19490 (KXD98_19395) 4125741..4125917 - 177 WP_260759964.1 hypothetical protein -
KXD98_RS19495 (KXD98_19400) 4125960..4126637 + 678 WP_260765321.1 guanylate cyclase -
KXD98_RS19500 (KXD98_19405) 4126746..4127357 + 612 WP_260759965.1 hypothetical protein -
KXD98_RS19505 (KXD98_19410) 4127421..4127699 + 279 WP_260759966.1 hypothetical protein -
KXD98_RS19510 (KXD98_19415) 4127709..4128203 + 495 WP_260759967.1 nitroreductase family deazaflavin-dependent oxidoreductase -
KXD98_RS19515 (KXD98_19420) 4128235..4128576 - 342 WP_260759968.1 hypothetical protein -
KXD98_RS19520 (KXD98_19425) 4129128..4129496 - 369 WP_260759969.1 type II toxin-antitoxin system VapC family toxin Toxin
KXD98_RS19525 (KXD98_19430) 4129493..4129687 - 195 WP_260759970.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KXD98_RS19530 (KXD98_19435) 4129748..4130821 - 1074 WP_260759971.1 redox-regulated ATPase YchF -
KXD98_RS19535 (KXD98_19440) 4130904..4132115 + 1212 WP_260759972.1 hypothetical protein -
KXD98_RS19540 (KXD98_19445) 4132112..4133830 - 1719 WP_260765322.1 penicillin-binding transpeptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13668.81 Da        Isoelectric Point: 5.5194

>T210266 WP_260759969.1 NZ_CP079869:c4129496-4129128 [Mycobacterium sp. SMC-4]
MILVDTAVWIDHLHAGESRLVEHLELDGVGCHPLVVEELALGSIARRNIVLDLLANLWQFPTAQHEEVLYLVERRQLWGR
GLSAVDAHLMAAVAMVEGARLWTRDKRLKAASREVGVALFDE

Download         Length: 369 bp

>T210266 NZ_CP104482:c4153424-4153140 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6841.81 Da        Isoelectric Point: 10.4580

>AT210266 WP_260759970.1 NZ_CP079869:c4129687-4129493 [Mycobacterium sp. SMC-4]
MRTTVTIDDDLLAKAAELTGVHENVALLKQGLQTLIRVESARRLAALGGSDSQAKAAPRRRASE

Download         Length: 195 bp

>AT210266 NZ_CP104482:c4153656-4153414 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References