Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 90123..90649 Replicon plasmid pSMC-8_2
Accession NZ_CP079867
Organism Mycobacterium sp. SMC-8

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag KXD97_RS32405 Protein ID WP_260758395.1
Coordinates 90347..90649 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag KXD97_RS32400 Protein ID WP_260758393.1
Coordinates 90123..90350 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD97_RS32380 (KXD97_32110) 85279..85800 - 522 WP_260758391.1 hypothetical protein -
KXD97_RS32385 (KXD97_32115) 85793..86509 - 717 WP_046361761.1 ParA family protein -
KXD97_RS32390 (KXD97_32120) 87883..88701 - 819 WP_260758392.1 IS21-like element helper ATPase IstB -
KXD97_RS32395 (KXD97_32125) 88701..89918 - 1218 WP_260758511.1 IS21 family transposase -
KXD97_RS32400 (KXD97_32130) 90123..90350 + 228 WP_260758393.1 ribbon-helix-helix protein, CopG family Antitoxin
KXD97_RS32405 (KXD97_32135) 90347..90649 + 303 WP_260758395.1 toxin Toxin
KXD97_RS32410 (KXD97_32140) 90765..92771 - 2007 WP_260758397.1 hypothetical protein -
KXD97_RS32415 (KXD97_32145) 93102..93389 - 288 WP_260758398.1 toxin-antitoxin system -
KXD97_RS32420 (KXD97_32150) 93530..93856 + 327 WP_260758400.1 type VII secretion target -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..114395 114395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10362.00 Da        Isoelectric Point: 4.6062

>T210265 WP_260758395.1 NZ_CP079867:90347-90649 [Mycobacterium sp. SMC-8]
VIAPGDIAPRRDTSHEVYVVVLSNSIHLAADTGRVIACPFIPGKIPDAAMAFVVRVGQPEGVALPELVQWLPAAALDEPI
GNIGANALRDTASLVTALVT

Download         Length: 303 bp

>T210265 NZ_CP104482:3644117-3644374 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8185.28 Da        Isoelectric Point: 5.6208

>AT210265 WP_260758393.1 NZ_CP079867:90123-90350 [Mycobacterium sp. SMC-8]
MAKDKVSITLDQDVLAAADADAKAAGLNRSELVEQALRHEHLRIALKSYMTTTVPALDIDDYAQKIYQANRASGL

Download         Length: 228 bp

>AT210265 NZ_CP104482:c3644292-3643960 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References