Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2556771..2557780 Replicon chromosome
Accession NZ_CP079865
Organism Mycobacterium sp. SMC-8

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag KXD97_RS12480 Protein ID WP_260757072.1
Coordinates 2556771..2557352 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag KXD97_RS12485 Protein ID WP_260757073.1
Coordinates 2557391..2557780 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD97_RS12465 (KXD97_12385) 2552358..2553512 + 1155 WP_260757068.1 DUF3322 and DUF2220 domain-containing protein -
KXD97_RS12470 (KXD97_12390) 2553670..2554998 - 1329 WP_260757069.1 plasmid pRiA4b ORF-3 family protein -
KXD97_RS12475 (KXD97_12395) 2555064..2556746 + 1683 WP_260757070.1 hypothetical protein -
KXD97_RS12480 (KXD97_12400) 2556771..2557352 - 582 WP_260757072.1 zeta toxin family protein Toxin
KXD97_RS12485 (KXD97_12405) 2557391..2557780 - 390 WP_260757073.1 ParD-like family protein Antitoxin
KXD97_RS12490 (KXD97_12410) 2557869..2558795 - 927 WP_260757074.1 ribonuclease H -
KXD97_RS12495 (KXD97_12415) 2558899..2561430 - 2532 WP_260757075.1 SEC-C domain-containing protein -
KXD97_RS12500 (KXD97_12420) 2561546..2562214 + 669 WP_260757076.1 response regulator transcription factor -
KXD97_RS12505 (KXD97_12425) 2562211..2562645 + 435 WP_260757077.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-148)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21191.07 Da        Isoelectric Point: 8.5170

>T210264 WP_260757072.1 NZ_CP079865:c2557352-2556771 [Mycobacterium sp. SMC-8]
VKRLDLVVGSNGAGKSTFIELTLAPLLPLSMYVNADEIAKRRWPEDPAGHSYEAARIAADTRARLIERGESFIAETVFSH
PSKLELLDAAHAADYTVILHAVLIPEDLAVLRVRHRVQAGGHDVPESKIRQRYQRLWDLVATAANRADEATFYDNSTTRG
PRIVAQLAAGIAVGSATWPSWTPAPLAHRWAGR

Download         Length: 582 bp

>T210264 NZ_CP104482:3455398-3455616 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13839.29 Da        Isoelectric Point: 6.0885

>AT210264 WP_260757073.1 NZ_CP079865:c2557780-2557391 [Mycobacterium sp. SMC-8]
MSDTTDRVTRVAADLMDSAATEGARQSRSAKQQLDHWARVGRAVSSQHSVARRRVEAALAGNIHLRELTDEEGVVFNAEI
SAAVQERLARADYGAVLAARGITTVALDDDGEIVQYAPDGSSVRLHRGA

Download         Length: 390 bp

>AT210264 NZ_CP104482:3454996-3455370 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References