Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2498023..2498561 Replicon chromosome
Accession NZ_CP079865
Organism Mycobacterium sp. SMC-8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KXD97_RS12250 Protein ID WP_260757041.1
Coordinates 2498023..2498280 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KXD97_RS12255 Protein ID WP_260757042.1
Coordinates 2498277..2498561 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD97_RS12230 (KXD97_12155) 2493848..2495191 + 1344 WP_260757038.1 MFS transporter -
KXD97_RS12235 (KXD97_12160) 2495283..2496092 + 810 WP_260757039.1 DUF1206 domain-containing protein -
KXD97_RS12240 (KXD97_12165) 2496298..2496729 + 432 WP_260757936.1 hypothetical protein -
KXD97_RS12245 (KXD97_12170) 2496845..2497990 + 1146 WP_260757040.1 serine hydrolase domain-containing protein -
KXD97_RS12250 (KXD97_12175) 2498023..2498280 - 258 WP_260757041.1 Txe/YoeB family addiction module toxin Toxin
KXD97_RS12255 (KXD97_12180) 2498277..2498561 - 285 WP_260757042.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KXD97_RS12260 (KXD97_12185) 2498696..2500171 - 1476 WP_260757043.1 hypothetical protein -
KXD97_RS12265 (KXD97_12190) 2500513..2500920 + 408 WP_260757044.1 hypothetical protein -
KXD97_RS12270 (KXD97_12195) 2501050..2501667 + 618 WP_260757045.1 FHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2454422..2536654 82232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10133.44 Da        Isoelectric Point: 8.5216

>T210263 WP_260757041.1 NZ_CP079865:c2498280-2498023 [Mycobacterium sp. SMC-8]
VRHINVDPDAWEDFLFWLASDRKTARRITRLIGEIQRDPFGGIGKPEPLKGELSGYWSRRIDDEHRLVYRADDHQVTILK
ARYHY

Download         Length: 258 bp

>T210263 NZ_CP104482:2402158-2402442 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGTCTTGAAAACCCTCGGGTTCCGGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10567.76 Da        Isoelectric Point: 4.6983

>AT210263 WP_260757042.1 NZ_CP079865:c2498561-2498277 [Mycobacterium sp. SMC-8]
MSISASEARQRLFPLLEQVNTDHEPVRITSRAGDAVLMSADDYDSWQETVYLLRSPENARRLMEAVARDKAGRHATPHLT
KSIDELQEMAGGEE

Download         Length: 285 bp

>AT210263 NZ_CP104482:2401920-2402168 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCATCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References