Detailed information of TA system TA210262

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES-Xre
• Location: 169695..170593
• Replicon: chromosome
• Accession: NZ_CP079865
• Organism: Mycobacterium sp. SMC-8

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: -
• Locus tag: KXD97_RS00930
• Protein ID: WP_260755037.1
• Coordinates: 169695..170255 (-)
• Length: 187 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: A0A4Y9N0V1
• Locus tag: KXD97_RS00935
• Protein ID: WP_011856840.1
• Coordinates: 170252..170593 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXD97_RS00910 (KXD97_00900)	165570..166190	+	621	WP_260755034.1	helix-turn-helix domain-containing protein	-
KXD97_RS00915 (KXD97_00905)	166280..167770	+	1491	WP_260755035.1	DDE-type integrase/transposase/recombinase	-
KXD97_RS00920 (KXD97_00910)	167809..168582	+	774	WP_260757981.1	AAA family ATPase	-
KXD97_RS00925 (KXD97_00915)	168659..169129	-	471	WP_260755036.1	hypothetical protein	-
KXD97_RS00930 (KXD97_00920)	169695..170255	-	561	WP_260755037.1	RES domain-containing protein	Toxin
KXD97_RS00935 (KXD97_00925)	170252..170593	-	342	WP_011856840.1	DUF2384 domain-containing protein	Antitoxin
KXD97_RS00940	170643..171401	+	759	WP_260755038.1	alkyl sulfatase C-terminal domain-containing protein	-
KXD97_RS00945 (KXD97_00940)	171910..172404	-	495	WP_011856867.1	hypothetical protein	-
KXD97_RS00950 (KXD97_00945)	172840..173454	+	615	WP_260755039.1	hypothetical protein	-
KXD97_RS00955 (KXD97_00950)	173572..174237	-	666	WP_046363128.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	158916..196607	37691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (28-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-110)

Sequences

Toxin

Protein

• Length: 187 a.a.
• Molecular weight: 20203.43 Da
• Isoelectric Point: 4.7491

>T210262 WP_260755037.1 NZ_CP079865:c170255-169695 [Mycobacterium sp. SMC-8]
VSDALDEDLVQRIDARGTNRWSGTCARYTGAHRDPLSGEGARRFGGRWNPAGLFSAIYLADSTQACMVEVERAAQAASTT
PEKMLEASYRLHTIEATDLAVLDLITSDAREAVGLEDDDIYGDDWSACQAVGHAAWFLHVQGVLVPAAGGIGLVITAYEQ
RTRPGQLHVSHSEDLTPIRYGELRHP

Nucleotide

• Length: 561 bp

>T210262 NZ_CP104482:2061927-2062030 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12323.09 Da
• Isoelectric Point: 4.7962

>AT210262 WP_011856840.1 NZ_CP079865:c170593-170252 [Mycobacterium sp. SMC-8]
MGANALASTVSSAIERLGLTYEEVGDIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLAHAKPADLVRDGEYQRVLALIDAMAEGIFV

Nucleotide

• Length: 342 bp

>AT210262 NZ_CP104482:c2062035-2061889 [Salmonella enterica]
CAAATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Structures

Antitoxin

• AlphaFold DB: A0A4Y9N0V1