Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5247197..5247863 Replicon chromosome
Accession NZ_CP079863
Organism Mycobacterium sp. SMC-2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag KXD96_RS24585 Protein ID WP_260741014.1
Coordinates 5247197..5247670 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag KXD96_RS24590 Protein ID WP_260741016.1
Coordinates 5247675..5247863 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD96_RS24565 (KXD96_24360) 5243493..5244719 + 1227 WP_260741006.1 acetyl-CoA acetyltransferase -
KXD96_RS24570 (KXD96_24365) 5244721..5246235 + 1515 WP_260745539.1 carotenoid oxygenase family protein -
KXD96_RS24575 (KXD96_24370) 5246235..5246717 + 483 WP_260741007.1 VOC family protein -
KXD96_RS24580 (KXD96_24375) 5246722..5247156 - 435 WP_260741011.1 hypothetical protein -
KXD96_RS24585 (KXD96_24380) 5247197..5247670 - 474 WP_260741014.1 SRPBCC family protein Toxin
KXD96_RS24590 (KXD96_24385) 5247675..5247863 - 189 WP_260741016.1 antitoxin Antitoxin
KXD96_RS24595 (KXD96_24390) 5247933..5250305 - 2373 WP_260741018.1 cation-translocating P-type ATPase -
KXD96_RS24600 (KXD96_24395) 5250302..5251888 - 1587 WP_260741020.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17028.64 Da        Isoelectric Point: 9.8215

>T210261 WP_260741014.1 NZ_CP079863:c5247670-5247197 [Mycobacterium sp. SMC-2]
MAKLSGSIDVPLPPEVAWKHASDLSRYKDWLTIHRVWRSTLPDDIDKGTVVESIVEVKGMYNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLLAKVRPAEEGSVVSFDVHLGGPALFGPIGMIVAAALRGDINESLQNFVAVFTRADPGTNGHGGVRR

Download         Length: 474 bp

>T210261 NZ_CP104482:c1012788-1012261 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATAAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6743.39 Da        Isoelectric Point: 4.5437

>AT210261 WP_260741016.1 NZ_CP079863:c5247863-5247675 [Mycobacterium sp. SMC-2]
MGFLDKAKDLLSQNADKVETAIDKAAEFVDDKTQGKYSDTIHQVQDEAKKAAESAAKGDDKN

Download         Length: 189 bp

>AT210261 NZ_CP104482:c1013075-1012785 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References