Detailed information of TA system TA210260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3782805..3783792
• Replicon: chromosome
• Accession: NZ_CP079863
• Organism: Mycobacterium sp. SMC-2

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: KXD96_RS17700
• Protein ID: WP_260738229.1
• Coordinates: 3782805..3783380 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: KXD96_RS17705
• Protein ID: WP_260738235.1
• Coordinates: 3783403..3783792 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXD96_RS17665 (KXD96_17515)	3777831..3778537	-	707	Protein_3503	DUF899 domain-containing protein	-
KXD96_RS17670 (KXD96_17520)	3778716..3779165	-	450	WP_260738216.1	nuclear transport factor 2 family protein	-
KXD96_RS17675 (KXD96_17525)	3779256..3779576	+	321	WP_260738218.1	hypothetical protein	-
KXD96_RS17680 (KXD96_17530)	3779608..3779838	+	231	WP_260738219.1	DUF167 domain-containing protein	-
KXD96_RS17685 (KXD96_17535)	3779962..3780774	+	813	WP_260738223.1	PPOX class F420-dependent oxidoreductase	-
KXD96_RS17690	3780854..3781153	-	300	WP_260738225.1	hypothetical protein	-
KXD96_RS17695 (KXD96_17545)	3781683..3782768	+	1086	WP_260738227.1	acetylserotonin O-methyltransferase	-
KXD96_RS17700 (KXD96_17550)	3782805..3783380	-	576	WP_260738229.1	zeta toxin family protein	Toxin
KXD96_RS17705 (KXD96_17555)	3783403..3783792	-	390	WP_260738235.1	ParD-like family protein	Antitoxin
KXD96_RS17710 (KXD96_17560)	3784195..3784998	-	804	WP_260736539.1	IS21-like element helper ATPase IstB	-
KXD96_RS17715 (KXD96_17565)	3784998..3786239	-	1242	WP_260736489.1	IS21 family transposase	-
KXD96_RS17720	3786404..3786565	+	162	WP_260738237.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-155)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 20961.04 Da
• Isoelectric Point: 10.1668

>T210260 WP_260738229.1 NZ_CP079863:c3783380-3782805 [Mycobacterium sp. SMC-2]
MKRLDLVVGPNGAGKSTFIALTLAPLLPRSVCVNADEIAKQRWPDDPLAHAYDAARVAADTRAKLIEAGVSFIAETVFSH
PSKLDLIRSAHDAGYTIALHVVLIPEDLAVERVKRRVRHGGHDVPEGKIRERHRRLWQFVADAVQIADTATVYDNSRRAG
PRIVAQFTAGTVIGAPTLPAWASEQLRRWPA

Nucleotide

• Length: 576 bp

>T210260 NZ_CP104482:852157-852555 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACGTCAAAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13726.93 Da
• Isoelectric Point: 4.3293

>AT210260 WP_260738235.1 NZ_CP079863:c3783792-3783403 [Mycobacterium sp. SMC-2]
MTNVADRVTRVAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSHQTASRHRVEAALAGRLDTNDLSEDEGLVFNAEI
SAAIEESLATTNYGDTLAAQGITTVALNDDGEIIEYRPDGTTAVVDADR

Nucleotide

• Length: 390 bp

>AT210260 NZ_CP104482:851930-852157 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA