Detailed information of TA system TA210257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK(toxin)
• Location: 5501095..5501675
• Replicon: chromosome
• Accession: NZ_CP079862
• Organism: Frankia sp. ArI3

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KZA76_RS22680
• Protein ID: WP_044884113.1
• Coordinates: 5501331..5501675 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: KZA76_RS22675
• Protein ID: WP_044884114.1
• Coordinates: 5501095..5501337 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZA76_RS22660	5496995..5498737	+	1743	WP_055409723.1	aldehyde dehydrogenase family protein	-
KZA76_RS22665	5499086..5500111	+	1026	WP_236706414.1	polyphosphate kinase 2	-
KZA76_RS22670	5500149..5501090	+	942	WP_044884115.1	pyridoxal-phosphate dependent enzyme	-
KZA76_RS22675	5501095..5501337	+	243	WP_044884114.1	ribbon-helix-helix domain-containing protein	Antitoxin
KZA76_RS22680	5501331..5501675	+	345	WP_044884113.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KZA76_RS22685	5501870..5503264	-	1395	WP_044884112.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 11874.80 Da
• Isoelectric Point: 10.7849

>T210257 WP_044884113.1 NZ_CP079862:5501331-5501675 [Frankia sp. ArI3]
MVISRGDIRWVDLGEAEGSRPAKRRPVVVVQSAPYNASRLATAVAVVITSNTVLATMPGNIFLPAAVTGLPRDSVANVAA
IVTVNKDELGHAVGAVPGGLMRDLDRGLRHVLGL

Nucleotide

• Length: 345 bp

>T210257 NZ_CP104482:322120-322488 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8746.54 Da
• Isoelectric Point: 4.1962

>AT210257 WP_044884114.1 NZ_CP079862:5501095-5501337 [Frankia sp. ArI3]
VKTAISIPDETFNEAERRAAALGVSRSEFFTTAARRYIEELDAQSLTERIDAALELAGPDDSFEAAARAGRRALGDSEDW

Nucleotide

• Length: 243 bp

>AT210257 NZ_CP104482:321902-322123 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA