Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 5220477..5220991 Replicon chromosome
Accession NZ_CP079862
Organism Frankia sp. ArI3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KZA76_RS21485 Protein ID WP_044884753.1
Coordinates 5220731..5220991 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KZA76_RS21480 Protein ID WP_044884754.1
Coordinates 5220477..5220734 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZA76_RS21460 5215824..5216750 + 927 WP_044884758.1 M56 family metallopeptidase -
KZA76_RS21465 5216968..5217201 + 234 WP_173667299.1 hypothetical protein -
KZA76_RS32500 5217347..5217535 + 189 Protein_4349 hypothetical protein -
KZA76_RS21470 5217774..5217992 + 219 WP_128423288.1 dienelactone hydrolase family protein -
KZA76_RS21475 5218034..5220355 + 2322 WP_044884755.1 CoA transferase -
KZA76_RS21480 5220477..5220734 + 258 WP_044884754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KZA76_RS21485 5220731..5220991 + 261 WP_044884753.1 Txe/YoeB family addiction module toxin Toxin
KZA76_RS21490 5221514..5221996 - 483 WP_236706000.1 DUF6326 family protein -
KZA76_RS21495 5222237..5222893 - 657 WP_009399358.1 response regulator transcription factor -
KZA76_RS21500 5222890..5223969 - 1080 WP_255648941.1 sensor histidine kinase -
KZA76_RS21510 5224717..5225316 + 600 WP_011605735.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10103.42 Da        Isoelectric Point: 8.0424

>T210255 WP_044884753.1 NZ_CP079862:5220731-5220991 [Frankia sp. ArI3]
VKLTWTDHAWDDYLYWQGQDRRTLKRINALIADIGRDPEGQGIGKPELLRNNLAGLRSRRIDDEHRLVYAVEPGQITIIA
CRYHYQ

Download         Length: 261 bp

>T210255 NZ_CP104479:c4719888-4719577 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9447.67 Da        Isoelectric Point: 4.7954

>AT210255 WP_044884754.1 NZ_CP079862:5220477-5220734 [Frankia sp. ArI3]
MVSAISASEARKTLFPLIEQVNTDHTPVEIVSKRGNAVLVSKEDWDAIVETNYLLRTPANARRLMESVEQWRTGGAVERP
VGPDE

Download         Length: 258 bp

>AT210255 NZ_CP104479:c4719576-4719286 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References