Detailed information of TA system TA210254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 2371934..2372634
• Replicon: chromosome
• Accession: NZ_CP079862
• Organism: Frankia sp. ArI3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KZA76_RS10020
• Protein ID: WP_044888587.1
• Coordinates: 2372209..2372634 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KZA76_RS10015
• Protein ID: WP_044888595.1
• Coordinates: 2371934..2372212 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZA76_RS09980	2367057..2367443	-	387	WP_044888591.1	hypothetical protein	-
KZA76_RS09985	2367508..2367747	+	240	WP_044888598.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KZA76_RS09990	2367744..2368004	+	261	WP_199865554.1	PIN domain-containing protein	-
KZA76_RS09995	2368214..2369146	+	933	WP_055871655.1	AraC family transcriptional regulator	-
KZA76_RS10000	2369469..2369930	+	462	WP_242419874.1	cupin domain-containing protein	-
KZA76_RS10005	2369927..2370775	+	849	WP_044888589.1	NmrA family NAD(P)-binding protein	-
KZA76_RS10010	2370854..2371828	+	975	WP_044888588.1	alpha/beta hydrolase	-
KZA76_RS10015	2371934..2372212	+	279	WP_044888595.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KZA76_RS10020	2372209..2372634	+	426	WP_044888587.1	type II toxin-antitoxin system VapC family toxin	Toxin
KZA76_RS10025	2372672..2373607	-	936	WP_044888586.1	SDR family oxidoreductase	-
KZA76_RS10030	2373761..2374372	+	612	WP_044888585.1	TetR/AcrR family transcriptional regulator	-
KZA76_RS10035	2374394..2375248	-	855	WP_044888584.1	helix-turn-helix transcriptional regulator	-
KZA76_RS10040	2375392..2376387	+	996	WP_044888594.1	aldo/keto reductase	-
KZA76_RS10045	2376460..2377218	-	759	WP_044888583.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2326481..2372634	46153

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-41)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15407.61 Da
• Isoelectric Point: 5.6941

>T210254 WP_044888587.1 NZ_CP079862:2372209-2372634 [Frankia sp. ArI3]
VIYLDSAAVVKLVVAEPESPALVDWLNVRDALPRFTSTLAEVEVTRAIRRAAPEALGRVPRVLDRMYRLEIDAHVRAVAA
AFDDPLLRSPDAIHLATALRLSDENDTRMEAFVTYDKRLLEAARRADLPTAAPGPHSAAGS

Nucleotide

• Length: 426 bp

>T210254 NZ_CP104479:c4409977-4409486 [Salmonella enterica]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATCCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10007.39 Da
• Isoelectric Point: 5.1351

>AT210254 WP_044888595.1 NZ_CP079862:2371934-2372212 [Frankia sp. ArI3]
VDRVGVRELNQSTSQVIDRVRRGETIEVTDRGRPVARLVPIGRGTAALDRLVTEGRAIPPATEGPVPMPPLLGDPAVSAT
NDLIAMRDEERW

Nucleotide

• Length: 279 bp

>AT210254 NZ_CP104479:c4410267-4409974 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA