Detailed information of TA system TA210249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 109580..110096
• Replicon: chromosome
• Accession: NZ_CP079860
• Organism: Vibrio neptunius strain KCTC 12702

Toxin (Protein)

• Gene name: relB
• Uniprot ID: U2ZZV8
• Locus tag: KW548_RS17125
• Protein ID: WP_005464459.1
• Coordinates: 109580..109849 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KW548_RS17130
• Protein ID: WP_219348934.1
• Coordinates: 109842..110096 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW548_RS17095 (KW548_17095)	105421..106275	+	855	WP_219348930.1	NAD(P)H-binding protein	-
KW548_RS17100 (KW548_17100)	106303..106451	-	149	Protein_106	IS256 family transposase	-
KW548_RS17105 (KW548_17105)	106567..106767	-	201	WP_219348931.1	hypothetical protein	-
KW548_RS17110	107300..107572	+	273	WP_219348932.1	hypothetical protein	-
KW548_RS17115 (KW548_17115)	108066..108920	+	855	WP_219348933.1	EamA family transporter	-
KW548_RS17120 (KW548_17120)	109371..109531	+	161	Protein_110	IS110 family transposase	-
KW548_RS17125 (KW548_17125)	109580..109849	-	270	WP_005464459.1	Txe/YoeB family addiction module toxin	Toxin
KW548_RS17130 (KW548_17130)	109842..110096	-	255	WP_219348934.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KW548_RS17135 (KW548_17135)	110396..110953	-	558	WP_219348935.1	cysteine hydrolase	-
KW548_RS17145 (KW548_17145)	112514..113035	-	522	WP_219348936.1	GNAT family N-acetyltransferase	-
KW548_RS17150 (KW548_17150)	113262..113561	-	300	WP_206376730.1	hypothetical protein	-
KW548_RS17155 (KW548_17155)	113668..113879	+	212	Protein_117	IS110 family transposase	-
KW548_RS17160 (KW548_17160)	113955..114425	-	471	WP_219348937.1	dual specificity protein phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10614.96 Da
• Isoelectric Point: 7.9816

>T210249 WP_005464459.1 NZ_CP079860:c109849-109580 [Vibrio neptunius]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T210249 NZ_CP104479:2462506-2462790 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9455.62 Da
• Isoelectric Point: 5.0622

>AT210249 WP_219348934.1 NZ_CP079860:c110096-109842 [Vibrio neptunius]
MKIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSITQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT210249 NZ_CP104479:2462268-2462516 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: U2ZZV8