Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 76924..77825 Replicon chromosome
Accession NZ_CP079860
Organism Vibrio neptunius strain KCTC 12702

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KW548_RS16900 Protein ID WP_206375602.1
Coordinates 76924..77385 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KW548_RS16905 Protein ID WP_206370987.1
Coordinates 77382..77825 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW548_RS16885 (KW548_16885) 73052..74296 + 1245 WP_206375605.1 multidrug effflux MFS transporter -
KW548_RS16890 (KW548_16890) 74413..75429 + 1017 WP_206375604.1 alpha/beta fold hydrolase -
KW548_RS16895 (KW548_16895) 75452..76498 - 1047 WP_206375603.1 helix-turn-helix domain-containing protein -
KW548_RS16900 (KW548_16900) 76924..77385 - 462 WP_206375602.1 RES family NAD+ phosphorylase Toxin
KW548_RS16905 (KW548_16905) 77382..77825 - 444 WP_206370987.1 DUF2384 domain-containing protein Antitoxin
KW548_RS25320 78014..78244 - 231 WP_257713501.1 GNAT family N-acetyltransferase -
KW548_RS25325 78222..78509 - 288 WP_257713502.1 GNAT family N-acetyltransferase -
KW548_RS25330 78733..78864 + 132 WP_257713503.1 hypothetical protein -
KW548_RS16915 (KW548_16915) 79012..80379 + 1368 WP_219348906.1 LysM peptidoglycan-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-136)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-88)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17335.62 Da        Isoelectric Point: 4.7145

>T210248 WP_206375602.1 NZ_CP079860:c77385-76924 [Vibrio neptunius]
MITLYRIVKEKWEESAFDGEGARLHGGRWNSIGRSAVYVSASESLAILEILVHLKNTKALENYVLFTLELDENDALVLEN
DDLPDNWNEEPAPLQTAEIGDQWLSSYSSLALAIPSVIVPREQNYVLNTKHPGYPKLIKTAKRHEISFDTRLL

Download         Length: 462 bp

>T210248 NZ_CP104479:c2101492-2101181 [Salmonella enterica]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAAAGATTTCTCTTCTCCGGCAGAGCTACGAACGGTCATACCGAGCCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTATTACAGGGAGAATAAAGAATGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16514.96 Da        Isoelectric Point: 9.4869

>AT210248 WP_206370987.1 NZ_CP079860:c77825-77382 [Vibrio neptunius]
MSQMQAFKPVKQPASFWQQVGIPSRGVTLYESVHKGLDFDVFDKLAKYSKLEKKELATAVTIPPATLNRRSKAGRFNKDE
SDRLYRFAEIFHQTINLFEGDIVAACEWLKSPVVGLGNRRPIDMVSTTAESEGVLNLIGRLEHGVFS

Download         Length: 444 bp

>AT210248 NZ_CP104479:c2101184-2100765 [Salmonella enterica]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTAGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGTGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References