Detailed information of TA system TA210244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 924140..924747
• Replicon: chromosome
• Accession: NZ_CP079855
• Organism: Agrobacterium fabrum strain LBA645

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q7D0B7
• Locus tag: KXJ62_RS04605
• Protein ID: WP_010971265.1
• Coordinates: 924140..924475 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A9CJP8
• Locus tag: KXJ62_RS04610
• Protein ID: WP_010971266.1
• Coordinates: 924472..924747 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ62_RS04590 (KXJ62_04585)	920245..922440	-	2196	WP_035256415.1	transglycosylase domain-containing protein	-
KXJ62_RS04595 (KXJ62_04590)	922697..923176	+	480	WP_010971263.1	YcgN family cysteine cluster protein	-
KXJ62_RS04600 (KXJ62_04595)	923288..924112	+	825	WP_010971264.1	class D beta-lactamase	-
KXJ62_RS04605 (KXJ62_04600)	924140..924475	-	336	WP_010971265.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KXJ62_RS04610 (KXJ62_04605)	924472..924747	-	276	WP_010971266.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KXJ62_RS04615 (KXJ62_04610)	924855..925463	+	609	WP_010971267.1	class I SAM-dependent methyltransferase	-
KXJ62_RS04620 (KXJ62_04615)	925639..928224	+	2586	WP_035256421.1	heavy metal translocating P-type ATPase	-
KXJ62_RS04625 (KXJ62_04620)	928221..928643	+	423	WP_006311241.1	Cu(I)-responsive transcriptional regulator	-
KXJ62_RS04630 (KXJ62_04625)	928696..928896	+	201	WP_006311242.1	heavy-metal-associated domain-containing protein	-
KXJ62_RS04635 (KXJ62_04630)	928966..929232	+	267	WP_010971270.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
KXJ62_RS04640 (KXJ62_04635)	929232..929591	+	360	WP_006311244.1	type II toxin-antitoxin system PemK/MazF family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (23-110)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12991.86 Da
• Isoelectric Point: 10.0059

>T210244 WP_010971265.1 NZ_CP079855:c924475-924140 [Agrobacterium fabrum]
VTNKKDHGKDAALKRATLPRRSDFTKQFIKDWQRLNNSGRYDMVRLKEIMLLLIANGAPLPTQFRDHELTGDWRDHRECH
VGGDFLLIYTVDEKQNLLIFTRAGTHAELFR

Nucleotide

• Length: 336 bp

>T210244 NZ_CP104479:405439-405714 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATTACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9918.40 Da
• Isoelectric Point: 6.3350

>AT210244 WP_010971266.1 NZ_CP079855:c924747-924472 [Agrobacterium fabrum]
MTANAYVRARIDQTLKDDATAVLDRLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAAGRNRFGTSE
ALFEALDAGKR

Nucleotide

• Length: 276 bp

>AT210244 NZ_CP104479:405176-405436 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGAATCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGGATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGACATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: Q7D0B7

Antitoxin

• AlphaFold DB: A9CJP8