Detailed information of TA system TA210243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 670257..670737
• Replicon: chromosome
• Accession: NZ_CP079855
• Organism: Agrobacterium fabrum strain LBA645

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A9CK22
• Locus tag: KXJ62_RS03315
• Protein ID: WP_010971059.1
• Coordinates: 670257..670526 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A9CK21
• Locus tag: KXJ62_RS03320
• Protein ID: WP_010971060.1
• Coordinates: 670510..670737 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ62_RS03285 (KXJ62_03280)	665308..666084	-	777	WP_010971054.1	L,D-transpeptidase	-
KXJ62_RS03290 (KXJ62_03285)	666323..666952	+	630	WP_010971055.1	DNA-3-methyladenine glycosylase I	-
KXJ62_RS03295 (KXJ62_03290)	666949..667392	+	444	WP_010972617.1	hypothetical protein	-
KXJ62_RS03300 (KXJ62_03295)	667418..668461	-	1044	WP_035256280.1	YeiH family protein	-
KXJ62_RS03305 (KXJ62_03300)	668543..669460	+	918	WP_010971057.1	LysR family transcriptional regulator	-
KXJ62_RS03310 (KXJ62_03305)	669486..670250	-	765	WP_010971058.1	hypothetical protein	-
KXJ62_RS03315 (KXJ62_03310)	670257..670526	-	270	WP_010971059.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KXJ62_RS03320 (KXJ62_03315)	670510..670737	-	228	WP_010971060.1	DUF6290 family protein	Antitoxin
KXJ62_RS03325 (KXJ62_03320)	670894..672417	+	1524	WP_010971061.1	histidine--tRNA ligase	-
KXJ62_RS03330 (KXJ62_03325)	672422..672790	+	369	WP_010971062.1	VOC family protein	-
KXJ62_RS03335 (KXJ62_03330)	672807..673934	+	1128	WP_010971063.1	ATP phosphoribosyltransferase regulatory subunit	-
KXJ62_RS03340 (KXJ62_03335)	673931..674623	+	693	WP_010971064.1	ATP phosphoribosyltransferase	-
KXJ62_RS03345 (KXJ62_03340)	674688..675134	-	447	WP_006313161.1	DoxX family protein	-
KXJ62_RS03350 (KXJ62_03345)	675290..675709	-	420	WP_230060738.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (6-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10746.46 Da
• Isoelectric Point: 9.9414

>T210243 WP_010971059.1 NZ_CP079855:c670526-670257 [Agrobacterium fabrum]
VIWTIEYHTLVQKEMRKINPEVRRRIRSFLHERLAALDDPRQIGATLQGSELGNFWRYRVGDYRIICDIQDQKLVVLVVE
IGHRREIYR

Nucleotide

• Length: 270 bp

>T210243 NZ_CP104479:357262-357630 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8937.97 Da
• Isoelectric Point: 4.7254

>AT210243 WP_010971060.1 NZ_CP079855:c670737-670510 [Agrobacterium fabrum]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRRIQRGESKIISAEEFWRDLDN

Nucleotide

• Length: 228 bp

>AT210243 NZ_CP104479:357044-357265 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A9CK22

Antitoxin

• AlphaFold DB: A9CK21