Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2681502..2682122 Replicon chromosome
Accession NZ_CP079839
Organism Salmonella enterica strain LHICA_E3

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JMJ87_RS12745 Protein ID WP_001280991.1
Coordinates 2681502..2681720 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JMJ87_RS12750 Protein ID WP_000344807.1
Coordinates 2681748..2682122 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ87_RS12705 (2676728) 2676728..2677297 + 570 WP_000779807.1 YbaY family lipoprotein -
JMJ87_RS12710 (2677330) 2677330..2677719 - 390 WP_077918938.1 MGMT family protein -
JMJ87_RS12720 (2677950) 2677950..2679500 - 1551 WP_000213152.1 EAL domain-containing protein -
JMJ87_RS12725 (2679725) 2679725..2679985 + 261 WP_000801414.1 type B 50S ribosomal protein L31 -
JMJ87_RS12730 (2679991) 2679991..2680131 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JMJ87_RS12735 (2680186) 2680186..2680656 - 471 WP_000136185.1 YlaC family protein -
JMJ87_RS12740 (2680772) 2680772..2681323 - 552 WP_001278785.1 maltose O-acetyltransferase -
JMJ87_RS12745 (2681502) 2681502..2681720 - 219 WP_001280991.1 HHA domain-containing protein Toxin
JMJ87_RS12750 (2681748) 2681748..2682122 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JMJ87_RS12755 (2682620) 2682620..2685769 - 3150 WP_001132503.1 efflux RND transporter permease AcrB -
JMJ87_RS12760 (2685792) 2685792..2686985 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T210232 WP_001280991.1 NZ_CP079839:c2681720-2681502 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210232 NZ_CP104476:c2411959-2411693 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT210232 WP_000344807.1 NZ_CP079839:c2682122-2681748 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT210232 NZ_CP104476:c2412210-2411959 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References