Detailed information of TA system TA210231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2064461..2066099
• Replicon: chromosome
• Accession: NZ_CP079839
• Organism: Salmonella enterica strain LHICA_E3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JMJ87_RS09945
• Protein ID: WP_079797941.1
• Coordinates: 2064771..2066099 (+)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A754E9C8
• Locus tag: JMJ87_RS09940
• Protein ID: WP_001314389.1
• Coordinates: 2064461..2064766 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ87_RS09925 (2059983)	2059983..2061086	-	1104	WP_079974448.1	reverse transcriptase family protein	-
JMJ87_RS09930 (2061259)	2061259..2063379	-	2121	WP_219165308.1	retron Eco8 family effector endonuclease	-
JMJ87_RS09935 (2063769)	2063769..2063924	-	156	WP_176580895.1	hypothetical protein	-
JMJ87_RS09940 (2064461)	2064461..2064766	+	306	WP_001314389.1	helix-turn-helix transcriptional regulator	Antitoxin
JMJ87_RS09945 (2064771)	2064771..2066099	+	1329	WP_079797941.1	type II toxin-antitoxin system HipA family toxin	Toxin
JMJ87_RS09950 (2066257)	2066257..2066526	-	270	WP_249264787.1	hypothetical protein	-
JMJ87_RS09955 (2066495)	2066495..2067391	-	897	WP_219165310.1	STY4528 family pathogenicity island replication protein	-
JMJ87_RS09960 (2067410)	2067410..2067949	-	540	WP_000938043.1	DUF2857 domain-containing protein	-
JMJ87_RS09965 (2067933)	2067933..2069417	-	1485	WP_079797940.1	chromosome partitioning protein ParB	-
JMJ87_RS09970 (2069414)	2069414..2070769	-	1356	WP_079797939.1	replicative DNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2030152..2072149	41997

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 50568.17 Da
• Isoelectric Point: 4.9618

>T210231 WP_079797941.1 NZ_CP079839:2064771-2066099 [Salmonella enterica]
MRRTQQRLAIWMNGIRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQSESLEPFDLLAELGRDCVGAIQLLDVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQIHWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPLELAECIFDGMRQQCGRLAERG

Nucleotide

• Length: 1329 bp

>T210231 NZ_CP104476:c2087428-2087219 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11363.02 Da
• Isoelectric Point: 10.1481

>AT210231 WP_001314389.1 NZ_CP079839:2064461-2064766 [Salmonella enterica]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMDESEQQKDSPARREKW

Nucleotide

• Length: 306 bp

>AT210231 NZ_CP104476:c2087733-2087440 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A754E9C8