Detailed information of TA system TA210230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1990303..1990819
• Replicon: chromosome
• Accession: NZ_CP079839
• Organism: Salmonella enterica strain LHICA_E3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V1HEI0
• Locus tag: JMJ87_RS09570
• Protein ID: WP_000220584.1
• Coordinates: 1990535..1990819 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JMJ87_RS09565
• Protein ID: WP_079797067.1
• Coordinates: 1990303..1990545 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ87_RS09545 (1985322)	1985322..1986455	+	1134	WP_000459961.1	amidohydrolase/deacetylase family metallohydrolase	-
JMJ87_RS09550 (1986439)	1986439..1987557	+	1119	WP_001139196.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
JMJ87_RS09555 (1987554)	1987554..1988294	+	741	WP_079974599.1	KDGP aldolase family protein	-
JMJ87_RS09560 (1988311)	1988311..1990224	+	1914	WP_141125049.1	BglG family transcription antiterminator	-
JMJ87_RS09565 (1990303)	1990303..1990545	+	243	WP_079797067.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JMJ87_RS09570 (1990535)	1990535..1990819	+	285	WP_000220584.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMJ87_RS09575 (1990829)	1990829..1991293	-	465	WP_046094240.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JMJ87_RS09580 (1991400)	1991400..1993538	-	2139	WP_053507663.1	anaerobic ribonucleoside-triphosphate reductase	-
JMJ87_RS09585 (1993947)	1993947..1995599	-	1653	WP_079974597.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11085.02 Da
• Isoelectric Point: 10.3015

>T210230 WP_000220584.1 NZ_CP079839:1990535-1990819 [Salmonella enterica]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Nucleotide

• Length: 285 bp

>T210230 NZ_CP104476:c2067824-2067462 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9041.44 Da
• Isoelectric Point: 5.0651

>AT210230 WP_079797067.1 NZ_CP079839:1990303-1990545 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDVLLQTVRERLANPQKGIRVSLDDL

Nucleotide

• Length: 243 bp

>AT210230 NZ_CP104476:c2067991-2067821 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A741MVA9