Detailed information of TA system TA210229

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yeeU/CbtA-CbeA
• Location: 1872709..1873397
• Replicon: chromosome
• Accession: NZ_CP079839
• Organism: Salmonella enterica strain LHICA_E3

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: JMJ87_RS08915
• Protein ID: WP_079797109.1
• Coordinates: 1872709..1873053 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JMJ87_RS08920
• Protein ID: WP_079797108.1
• Coordinates: 1873068..1873397 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ87_RS08895 (1868210)	1868210..1868429	-	220	Protein_1722	hypothetical protein	-
JMJ87_RS08900 (1869113)	1869113..1870114	+	1002	WP_079797112.1	BsuBI/PstI family type II restriction endonuclease	-
JMJ87_RS08905 (1870164)	1870164..1871693	-	1530	WP_079797111.1	Eco57I restriction-modification methylase domain-containing protein	-
JMJ87_RS08910 (1871762)	1871762..1872595	-	834	WP_079974617.1	DUF4942 domain-containing protein	-
JMJ87_RS08915 (1872709)	1872709..1873053	-	345	WP_079797109.1	TA system toxin CbtA family protein	Toxin
JMJ87_RS08920 (1873068)	1873068..1873397	-	330	WP_079797108.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JMJ87_RS08925 (1873460)	1873460..1873942	-	483	WP_079797107.1	DNA repair protein RadC	-
JMJ87_RS08930 (1873954)	1873954..1874394	-	441	WP_079797106.1	antirestriction protein	-
JMJ87_RS08935 (1874532)	1874532..1875353	-	822	WP_079974616.1	DUF932 domain-containing protein	-
JMJ87_RS08940 (1875432)	1875432..1875671	-	240	WP_079797104.1	DUF905 family protein	-
JMJ87_RS08945 (1875786)	1875786..1876451	-	666	WP_141125052.1	hypothetical protein	-
JMJ87_RS08950 (1876417)	1876417..1876725	-	309	WP_079974614.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1866784..1885352	18568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-109)

Antitoxin

• Antitoxin CbeA (10-108)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13068.00 Da
• Isoelectric Point: 7.8816

>T210229 WP_079797109.1 NZ_CP079839:c1873053-1872709 [Salmonella enterica]
MQNVLSLPSPAAAPSRLSPIEAWRKLLSYLLQRHYGLELNDTPFCDDIVIQEHINAGITLADAVNFLVEKYELVRIDRRG
FNCQEQSPYLWAVDILRARQATGLLRQSRHPPTR

Nucleotide

• Length: 345 bp

>T210229 NZ_CP104476:c1909600-1909448 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12204.76 Da
• Isoelectric Point: 6.7066

>AT210229 WP_079797108.1 NZ_CP079839:c1873397-1873068 [Salmonella enterica]
MSQNQPSMPVWGLRSDITPSFGARLVQEGRRLHFLADRASLCGDFTLEQLKTLDATFSQFLKQLESALKSGALDPRQPHR
HNITLNGLTCEADTNGSYGYVYLTIYPTE

Nucleotide

• Length: 330 bp

>AT210229 NZ_CP104476:c1910224-1909625 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA