Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4449753..4450441 Replicon chromosome
Accession NZ_CP079838
Organism Salmonella enterica subsp. salamae strain LHICA_SA3

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag JMJ83_RS21445 Protein ID WP_079797109.1
Coordinates 4450097..4450441 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JMJ83_RS21440 Protein ID WP_079797108.1
Coordinates 4449753..4450082 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ83_RS21415 (4446426) 4446426..4447364 + 939 WP_219190702.1 hypothetical protein -
JMJ83_RS21420 (4447479) 4447479..4447718 + 240 WP_079797104.1 DUF905 family protein -
JMJ83_RS21425 (4447797) 4447797..4448618 + 822 WP_079974616.1 DUF932 domain-containing protein -
JMJ83_RS21430 (4448756) 4448756..4449196 + 441 WP_079797106.1 antirestriction protein -
JMJ83_RS21435 (4449208) 4449208..4449690 + 483 WP_079797107.1 DNA repair protein RadC -
JMJ83_RS21440 (4449753) 4449753..4450082 + 330 WP_079797108.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMJ83_RS21445 (4450097) 4450097..4450441 + 345 WP_079797109.1 TA system toxin CbtA family protein Toxin
JMJ83_RS21450 (4450555) 4450555..4451388 + 834 WP_079974617.1 DUF4942 domain-containing protein -
JMJ83_RS21455 (4451457) 4451457..4452986 + 1530 WP_079797111.1 Eco57I restriction-modification methylase domain-containing protein -
JMJ83_RS21460 (4453036) 4453036..4454037 - 1002 WP_079797112.1 BsuBI/PstI family type II restriction endonuclease -
JMJ83_RS21465 (4454721) 4454721..4454940 + 220 Protein_4226 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4438148..4457536 19388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-109)

Antitoxin

Antitoxin CbeA

(10-108)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13068.00 Da        Isoelectric Point: 7.8816

>T210224 WP_079797109.1 NZ_CP079838:4450097-4450441 [Salmonella enterica subsp. salamae]
MQNVLSLPSPAAAPSRLSPIEAWRKLLSYLLQRHYGLELNDTPFCDDIVIQEHINAGITLADAVNFLVEKYELVRIDRRG
FNCQEQSPYLWAVDILRARQATGLLRQSRHPPTR

Download         Length: 345 bp

>T210224 NZ_CP104472:c4975463-4975356 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCATAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12204.76 Da        Isoelectric Point: 6.7066

>AT210224 WP_079797108.1 NZ_CP079838:4449753-4450082 [Salmonella enterica subsp. salamae]
MSQNQPSMPVWGLRSDITPSFGARLVQEGRRLHFLADRASLCGDFTLEQLKTLDATFSQFLKQLESALKSGALDPRQPHR
HNITLNGLTCEADTNGSYGYVYLTIYPTE

Download         Length: 330 bp

>AT210224 NZ_CP104472:4975516-4975577 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGGTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References