Detailed information of TA system TA210222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4257044..4258682
• Replicon: chromosome
• Accession: NZ_CP079838
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JMJ83_RS20420
• Protein ID: WP_079797941.1
• Coordinates: 4257044..4258372 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A754E9C8
• Locus tag: JMJ83_RS20425
• Protein ID: WP_001314389.1
• Coordinates: 4258377..4258682 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ83_RS20395 (4252374)	4252374..4253729	+	1356	WP_219190692.1	replicative DNA helicase	-
JMJ83_RS20400 (4253726)	4253726..4255210	+	1485	WP_079797940.1	chromosome partitioning protein ParB	-
JMJ83_RS20405 (4255194)	4255194..4255733	+	540	WP_000938043.1	DUF2857 domain-containing protein	-
JMJ83_RS20410 (4255752)	4255752..4256648	+	897	WP_219165310.1	STY4528 family pathogenicity island replication protein	-
JMJ83_RS20415 (4256617)	4256617..4256886	+	270	WP_249264787.1	hypothetical protein	-
JMJ83_RS20420 (4257044)	4257044..4258372	-	1329	WP_079797941.1	type II toxin-antitoxin system HipA family toxin	Toxin
JMJ83_RS20425 (4258377)	4258377..4258682	-	306	WP_001314389.1	helix-turn-helix transcriptional regulator	Antitoxin
JMJ83_RS20430 (4259219)	4259219..4259374	+	156	WP_176580895.1	hypothetical protein	-
JMJ83_RS20435 (4259764)	4259764..4261884	+	2121	WP_079974447.1	retron Eco8 family effector endonuclease	-
JMJ83_RS20440 (4262057)	4262057..4263160	+	1104	WP_079974448.1	reverse transcriptase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4250994..4292999	42005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 50568.17 Da
• Isoelectric Point: 4.9618

>T210222 WP_079797941.1 NZ_CP079838:c4258372-4257044 [Salmonella enterica subsp. salamae]
MRRTQQRLAIWMNGIRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQSESLEPFDLLAELGRDCVGAIQLLDVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQIHWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPLELAECIFDGMRQQCGRLAERG

Nucleotide

• Length: 1329 bp

>T210222 NZ_CP104472:c4067295-4067077 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11363.02 Da
• Isoelectric Point: 10.1481

>AT210222 WP_001314389.1 NZ_CP079838:c4258682-4258377 [Salmonella enterica subsp. salamae]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMDESEQQKDSPARREKW

Nucleotide

• Length: 306 bp

>AT210222 NZ_CP104472:c4067695-4067321 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A754E9C8