Detailed information of TA system TA210221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3639493..3640113
• Replicon: chromosome
• Accession: NZ_CP079838
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA3

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: JMJ83_RS17615
• Protein ID: WP_001280991.1
• Coordinates: 3639895..3640113 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: JMJ83_RS17610
• Protein ID: WP_000344807.1
• Coordinates: 3639493..3639867 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ83_RS17600 (3634630)	3634630..3635823	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
JMJ83_RS17605 (3635846)	3635846..3638995	+	3150	WP_001132503.1	efflux RND transporter permease AcrB	-
JMJ83_RS17610 (3639493)	3639493..3639867	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
JMJ83_RS17615 (3639895)	3639895..3640113	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
JMJ83_RS17620 (3640292)	3640292..3640843	+	552	WP_001278785.1	maltose O-acetyltransferase	-
JMJ83_RS17625 (3640959)	3640959..3641429	+	471	WP_000136185.1	YlaC family protein	-
JMJ83_RS17630 (3641484)	3641484..3641624	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
JMJ83_RS17635 (3641630)	3641630..3641890	-	261	WP_000801414.1	type B 50S ribosomal protein L31	-
JMJ83_RS17640 (3642115)	3642115..3643665	+	1551	WP_000213152.1	EAL domain-containing protein	-
JMJ83_RS17650 (3643896)	3643896..3644285	+	390	WP_077918938.1	MGMT family protein	-
JMJ83_RS17655 (3644318)	3644318..3644887	-	570	WP_000779807.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T210221 WP_001280991.1 NZ_CP079838:3639895-3640113 [Salmonella enterica subsp. salamae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T210221 NZ_CP104472:c4033322-4032780 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT210221 WP_000344807.1 NZ_CP079838:3639493-3639867 [Salmonella enterica subsp. salamae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT210221 NZ_CP104472:c4033617-4033306 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0