Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 979287..979947 Replicon chromosome
Accession NZ_CP079838
Organism Salmonella enterica subsp. salamae strain LHICA_SA3

Toxin (Protein)


Gene name cptA Uniprot ID A0A701Y5L0
Locus tag JMJ83_RS04770 Protein ID WP_000244758.1
Coordinates 979534..979947 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag JMJ83_RS04765 Protein ID WP_000351186.1
Coordinates 979287..979553 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ83_RS04745 (975224) 975224..976657 - 1434 WP_079974061.1 6-phospho-beta-glucosidase BglA -
JMJ83_RS04750 (976815) 976815..977126 + 312 WP_001182973.1 N(4)-acetylcytidine aminohydrolase -
JMJ83_RS04755 (977290) 977290..977949 + 660 WP_023180797.1 hemolysin III family protein -
JMJ83_RS04760 (978057) 978057..979037 - 981 WP_000874162.1 tRNA-modifying protein YgfZ -
JMJ83_RS04765 (979287) 979287..979553 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
JMJ83_RS04770 (979534) 979534..979947 + 414 WP_000244758.1 protein YgfX Toxin
JMJ83_RS04775 (980000) 980000..980521 - 522 WP_058114568.1 flavodoxin FldB -
JMJ83_RS04780 (980634) 980634..981530 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
JMJ83_RS04785 (981554) 981554..982267 + 714 WP_079797899.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMJ83_RS04790 (982273) 982273..984006 + 1734 WP_000813384.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16249.21 Da        Isoelectric Point: 10.7538

>T210210 WP_000244758.1 NZ_CP079838:979534-979947 [Salmonella enterica subsp. salamae]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMLLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRIVLQQPISRQH

Download         Length: 414 bp

>T210210 NZ_CP104472:c1754887-1754480 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGTCGAATGGCGGGTTTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT210210 WP_000351186.1 NZ_CP079838:979287-979553 [Salmonella enterica subsp. salamae]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210210 NZ_CP104472:c1755134-1754868 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A701Y5L0

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References