Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4242699..4243474 Replicon chromosome
Accession NZ_CP079837
Organism Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag JMJ84_RS20335 Protein ID WP_219141342.1
Coordinates 4242699..4243184 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag JMJ84_RS20340 Protein ID WP_219141343.1
Coordinates 4243181..4243474 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ84_RS23155 (4240526) 4240526..4240855 + 330 WP_257590037.1 hypothetical protein -
JMJ84_RS23160 (4241086) 4241086..4241430 + 345 WP_257590038.1 hypothetical protein -
JMJ84_RS20325 (4241734) 4241734..4241985 + 252 WP_024131240.1 hypothetical protein -
JMJ84_RS20330 (4242067) 4242067..4242519 + 453 WP_000434168.1 hypothetical protein -
JMJ84_RS20335 (4242699) 4242699..4243184 - 486 WP_219141342.1 GNAT family N-acetyltransferase Toxin
JMJ84_RS20340 (4243181) 4243181..4243474 - 294 WP_219141343.1 DUF1778 domain-containing protein Antitoxin
JMJ84_RS20345 (4243965) 4243965..4244184 + 220 Protein_4002 hypothetical protein -
JMJ84_RS20350 (4244449) 4244449..4245324 + 876 WP_219141344.1 AraC family transcriptional regulator -
JMJ84_RS20355 (4245321) 4245321..4245608 + 288 WP_077907410.1 transcriptional regulator RtsB -
JMJ84_RS20360 (4245910) 4245910..4247895 - 1986 WP_219141345.1 ATP-binding cassette domain-containing protein -
JMJ84_RS20365 (4247892) 4247892..4248266 - 375 WP_257590039.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.52 Da        Isoelectric Point: 7.7536

>T210205 WP_219141342.1 NZ_CP079837:c4243184-4242699 [Salmonella enterica subsp. salamae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDVKVMAYYSLASSAVATNTAPGRFRRNMPDPI
PVVVLGRLAVDQSLHGRGVGRALMRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVH
A

Download         Length: 486 bp

>T210205 NZ_CP104472:c653367-653264 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10904.52 Da        Isoelectric Point: 9.8590

>AT210205 WP_219141343.1 NZ_CP079837:c4243474-4243181 [Salmonella enterica subsp. salamae]
MPAANSMAMKRETLNLRIKPAERDLIDRGAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQAFLTRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT210205 NZ_CP104472:653226-653497 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References