Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4014443..4015086 Replicon chromosome
Accession NZ_CP079837
Organism Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)


Gene name vagD Uniprot ID A0A729PX92
Locus tag JMJ84_RS19115 Protein ID WP_001804122.1
Coordinates 4014670..4015086 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A734MGW9
Locus tag JMJ84_RS19110 Protein ID WP_023180079.1
Coordinates 4014443..4014673 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ84_RS19100 (4011457) 4011457..4013595 + 2139 WP_053507663.1 anaerobic ribonucleoside-triphosphate reductase -
JMJ84_RS19105 (4013812) 4013812..4014276 + 465 WP_219141254.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMJ84_RS19110 (4014443) 4014443..4014673 + 231 WP_023180079.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JMJ84_RS19115 (4014670) 4014670..4015086 + 417 WP_001804122.1 type II toxin-antitoxin system VapC family toxin Toxin
JMJ84_RS19120 (4015146) 4015146..4017059 - 1914 WP_150363067.1 BglG family transcription antiterminator -
JMJ84_RS19125 (4017076) 4017076..4017816 - 741 WP_219141255.1 KDGP aldolase family protein -
JMJ84_RS19130 (4017813) 4017813..4018931 - 1119 WP_001139196.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
JMJ84_RS19135 (4018915) 4018915..4020048 - 1134 WP_079808651.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15193.54 Da        Isoelectric Point: 8.1389

>T210203 WP_001804122.1 NZ_CP079837:4014670-4015086 [Salmonella enterica subsp. salamae]
MSRTYMLDTCICSFIMREQPEAVLKRLEQTVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T210203 NZ_CP104472:c284002-282680 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8891.90 Da        Isoelectric Point: 4.6677

>AT210203 WP_023180079.1 NZ_CP079837:4014443-4014673 [Salmonella enterica subsp. salamae]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKANPDFLTEREDIVSDEGRFEL

Download         Length: 231 bp

>AT210203 NZ_CP104472:c284268-284002 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A729PX92

Antitoxin

Source ID Structure
AlphaFold DB A0A734MGW9

References