Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3358466..3359086 Replicon chromosome
Accession NZ_CP079837
Organism Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JMJ84_RS16075 Protein ID WP_001280991.1
Coordinates 3358868..3359086 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JMJ84_RS16070 Protein ID WP_000344807.1
Coordinates 3358466..3358840 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ84_RS16060 (3353603) 3353603..3354796 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMJ84_RS16065 (3354819) 3354819..3357968 + 3150 WP_001132503.1 efflux RND transporter permease AcrB -
JMJ84_RS16070 (3358466) 3358466..3358840 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JMJ84_RS16075 (3358868) 3358868..3359086 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JMJ84_RS16080 (3359265) 3359265..3359816 + 552 WP_001278785.1 maltose O-acetyltransferase -
JMJ84_RS16085 (3359932) 3359932..3360402 + 471 WP_000136185.1 YlaC family protein -
JMJ84_RS16090 (3360457) 3360457..3360597 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JMJ84_RS16095 (3360603) 3360603..3360863 - 261 WP_000801414.1 type B 50S ribosomal protein L31 -
JMJ84_RS16100 (3361088) 3361088..3362638 + 1551 WP_219141068.1 EAL domain-containing protein -
JMJ84_RS16110 (3362869) 3362869..3363258 + 390 WP_077918938.1 MGMT family protein -
JMJ84_RS16115 (3363291) 3363291..3363860 - 570 WP_000779807.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T210202 WP_001280991.1 NZ_CP079837:3358868-3359086 [Salmonella enterica subsp. salamae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210202 NZ_CP104472:186880-187056 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT210202 WP_000344807.1 NZ_CP079837:3358466-3358840 [Salmonella enterica subsp. salamae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT210202 NZ_CP104472:187102-187518 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References